SPRED3 sprouty-related, EVH1 domain containing 3 [Homo sapiens] - Gene

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Summary

Official Symbol: SPRED3provided by HGNC
Official Full Name: sprouty-related, EVH1 domain containing 3provided by HGNC
Primary source: HGNC:31041
See related: Ensembl:ENSG00000188766; MIM:609293
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Eve-3
Summary: SPRED3 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

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Genomic context

Location :: 19q13

Sequence :: Chromosome: 19; NC_000019.9 (38880939..38886871)

See SPRED3 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Eve-3 may act as an inhibitor of proliferation pathways in the mature liver and be involved in modulating the unique regenerative capacity of this organ
Title: Eve-3: a liver enriched suppressor of Ras/MAPK signaling.
The finding of Spred-3 revealed the presence of a novel family of regulators for the Ras/MAP kinase pathway, each member of which may have different specificities for extracellular signals. [Spred-3]
Title: Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:134352	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-Western

Process	Evidence Code	Pubs
multicellular organismal development	IEA Inferred from Electronic Annotation more info
regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: sprouty-related, EVH1 domain-containing protein 3

Names: sprouty-related, EVH1 domain-containing protein 3; spred-3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039616.1 → NP_001034705.1 sprouty-related, EVH1 domain-containing protein 3 isoform b

Status: VALIDATED

Source sequence(s)

DQ323927

Consensus CDS

CCDS42561.1

UniProtKB/Swiss-Prot

Q2MJR0

Related

ENSP00000380086, ENST00000396877

Conserved Domains (1) summary

cl00273
Location:48 – 105
Blast Score: 171

PH-like; Pleckstrin homology-like domain
NM_001042522.1 → NP_001035987.1 sprouty-related, EVH1 domain-containing protein 3 isoform a

Status: VALIDATED

Source sequence(s)

DQ323928

Consensus CDS

CCDS42560.1

UniProtKB/Swiss-Prot

Q2MJR0

Related

ENSP00000345405, ENST00000338502

Conserved Domains (2) summary

pfam05210
Location:297 – 392
Blast Score: 211

Sprouty; Sprouty protein (Spry)

cl00273
Location:48 – 105
Blast Score: 177

PH-like; Pleckstrin homology-like domain