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    Nc73EF Neural conserved at 73EF [ Drosophila melanogaster ]

    Gene ID: 39899, updated on 19-May-2012
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    Summary

    Official Symbol
    Nc73EFprovided by Flybase
    Official Full Name
    Neural conserved at 73EFprovided by Flybase
    Primary source
    FLYBASE:FBgn0010352
    Locus tag
    Dmel_CG11661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141810_at; anon-WO0118547.329; CG11661; Dmel\CG11661; E1; FBgn0036682
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    Genomic context

    Location :
    73E1-73E1
    Sequence :
    Chromosome: 3L; NT_037436.3 (16948605..16961180)
    See Nc73EF in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene Cuticular protein 73D Neighboring gene CG13027 gene product from transcript CG13027-RB Neighboring gene Ephexin Neighboring gene CG3764 gene product from transcript CG3764-RA Neighboring gene mir-2500 stem loop

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626.
    3. A microtubule interactome: complexes with roles in cell cycle and mitosis. Hughes JR, et al. PLoS Biol, 2008 Apr 22. PMID 18433294.
    4. Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Chen J, et al. Genome Res, 2008 Jan. PMID 18042644.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:65194 BioGRID:68866 Acon    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:57710 Actn    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:533474 Adh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:64208 CG10075    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:61198 CG13085    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:72488 CG17450    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:76824 CG32819    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:76825 CG32820    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:64758 CG4328    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:64078 CG4769    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:62952 CG9090    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:68567 CycG    BioGRID  PubMed Two-hybrid 
    BioGRID:65194 BioGRID:67768 Gdh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:59989 Gpdh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:66889 Mf    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:68443 Mlc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:68907 Pdsw    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:78227 Scp1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:66917 Tm2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:58691 up    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65194 BioGRID:59114 wupA    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    oxoglutarate dehydrogenase (succinyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial oxoglutarate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    CG11661 gene product from transcript CG11661-RC
    Names
    CG11661-PA
    CG11661-PB
    CG11661-PC
    CG11661-PF
    CG11661-PG
    CG11661-PH
    CG11661-PI
    Nc73EF-PA
    Nc73EF-PB
    Nc73EF-PC
    Nc73EF-PF
    Nc73EF-PG
    Nc73EF-PH
    Nc73EF-PI
    alpha-ketoglutarate dehydrogenase E1 subunit
    neural conserved at 73EF
    neural conserved at 73KF
    NP_001097629.1
    NP_730223.1
    NP_730224.1
    NP_730225.1
    NP_788518.1
    NP_788519.1
    NP_788520.2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      16948605..16961180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168703.3 → NP_730225.1  neural conserved at 73EF, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075023, FBtr0075263
      Conserved Domains (3) summary
      cd02016
      Location:259 – 521
      Blast Score: 1179
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 1007
      Blast Score: 3357
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:645 – 858
      Blast Score: 434
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.

    2. NM_176340.2 → NP_788518.1  neural conserved at 73EF, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQQ0
      Related
      FBpp0075027, FBtr0075267
      Conserved Domains (3) summary
      cd02016
      Location:268 – 530
      Blast Score: 1179
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 1016
      Blast Score: 3346
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:654 – 867
      Blast Score: 434
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.

    3. NM_176341.2 → NP_788519.1  neural conserved at 73EF, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075028, FBtr0075268
      Conserved Domains (3) summary
      cd02016
      Location:259 – 521
      Blast Score: 1179
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 1007
      Blast Score: 3357
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:645 – 858
      Blast Score: 434
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.

    4. NM_168702.2 → NP_730224.1  neural conserved at 73EF, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075024, FBtr0075264
      Conserved Domains (3) summary
      cd02016
      Location:259 – 521
      Blast Score: 1179
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 1007
      Blast Score: 3357
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:645 – 858
      Blast Score: 434
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.

    5. NM_168701.3 → NP_730223.1  neural conserved at 73EF, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075026, FBtr0075266
      Conserved Domains (3) summary
      cd02016
      Location:259 – 521
      Blast Score: 1179
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 1007
      Blast Score: 3357
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:645 – 858
      Blast Score: 434
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.

    6. NM_176342.3 → NP_788520.2  neural conserved at 73EF, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQQ0
      Related
      FBpp0075029, FBtr0075269
      Conserved Domains (3) summary
      cd02016
      Location:268 – 530
      Blast Score: 1179
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 1016
      Blast Score: 3346
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:654 – 867
      Blast Score: 434
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.

    7. NM_001104159.2 → NP_001097629.1  neural conserved at 73EF, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNU6
      Related
      FBpp0111773, FBtr0112860
      Conserved Domains (3) summary
      cd02016
      Location:259 – 521
      Blast Score: 1178
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      PRK09404
      Location:53 – 975
      Blast Score: 3259
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cl11410
      Location:645 – 858
      Blast Score: 435
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAN11722.1
    genomic AE014296.4 AAF49389.2
    mRNA BT003743.1 AAO41404.1
    genomic AE014296.4 AAO41240.1
    genomic AE014296.4 AAF49388.2
    genomic AE014296.4 AAO41241.2
    mRNA BT012466.1 AAS93737.1
    genomic AE014296.4 AAN11721.1
    genomic AE014296.4 ABW08558.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVC5.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content