These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029895.1 RefSeqGene
- Range
- 5001..72817
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001031801.1 → NP_001026971.1 LIM domain kinase 2 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
BC013051, BU553494
- Consensus CDS
-
CCDS33637.1
- Related
- ENSP00000339916, OTTHUMP00000199484, ENST00000340552, OTTHUMT00000321913
- Conserved Domains (6) summary
-
- cd00992
Location:129 – 215
Blast Score: 125
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- pfam05361
Location:590 – 685
Blast Score: 280
- PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
- cd00180
Location:316 – 518
Blast Score: 465
- PKc; Catalytic domain of Protein Kinases
- cd09465
Location:46 – 104
Blast Score: 345
- LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
- smart00221
Location:313 – 565
Blast Score: 468
- STYKc; Protein kinase; unclassified specificity.
- cl02475
Location:15 – 44
Blast Score: 180
- LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.
-
NM_005569.3 → NP_005560.1 LIM domain kinase 2 isoform 2a
Status: REVIEWED
- Description
- Transcript Variant: This variant (2a) differs in the 5' UTR and coding region as well as the 3' UTR and coding region, compared to variant 1. The resulting isoform (2a) is shorter and has distinct N- and C-termini compared to isoform 1.
- Source sequence(s)
-
AC002073, BC013051, BX385507, D45906
- Consensus CDS
-
CCDS13891.1
- UniProtKB/Swiss-Prot
-
P53671
- Related
- ENSP00000332687, OTTHUMP00000199482, ENST00000331728, OTTHUMT00000321911
- Conserved Domains (5) summary
-
- cd00992
Location:150 – 236
Blast Score: 126
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd09463
Location:12 – 65
Blast Score: 301
- LIM1_LIMK2; The first LIM domain of LIMK2 (LIM domain Kinase 2)
- cd09465
Location:67 – 125
Blast Score: 341
- LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
- smart00221
Location:334 – 601
Blast Score: 519
- STYKc; Protein kinase; unclassified specificity.
- cl09925
Location:335 – 602
Blast Score: 504
- PKc_like; Protein Kinases, catalytic domain
-
NM_016733.2 → NP_057952.1 LIM domain kinase 2 isoform 2b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2b) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (2b) is shorter and has a distinct C-terminus compared to isoform 1.
- Source sequence(s)
-
AC002073, BC013051, BU553494
- Consensus CDS
-
CCDS13892.1
- UniProtKB/Swiss-Prot
-
P53671
- Related
- ENSP00000330470, OTTHUMP00000199485, ENST00000333611, OTTHUMT00000321914
- Conserved Domains (5) summary
-
- cd00992
Location:129 – 215
Blast Score: 126
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd09465
Location:46 – 104
Blast Score: 343
- LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
- smart00221
Location:313 – 580
Blast Score: 519
- STYKc; Protein kinase; unclassified specificity.
- cl02475
Location:15 – 44
Blast Score: 182
- LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.
- cl09925
Location:314 – 581
Blast Score: 503
- PKc_like; Protein Kinases, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000022.10 Reference GRCh37.p5 Primary Assembly
- Range
- 31608250..31676066
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000154.1 Alternate HuRef
- Range
- 14569980..14637678
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)