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    Aats-tyr Tyrosyl-tRNA synthetase [ Drosophila melanogaster ]

    Gene ID: 39829, updated on 10-May-2012
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    Summary

    Official Symbol
    Aats-tyrprovided by Flybase
    Official Full Name
    Tyrosyl-tRNA synthetaseprovided by Flybase
    Primary source
    FLYBASE:FBgn0027080
    Locus tag
    Dmel_CG4561
    Gene type
    protein coding
    RNA name
    Tyrosyl-tRNA synthetase
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey261; CG4561; Dmel\CG4561; dYARS; TyrRS; YRS
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    Genomic context

    Location :
    72F1-72F1
    Sequence :
    Chromosome: 3L; NT_037436.3 (16410447..16412395, complement)
    See Aats-tyr in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene failed axon connections Neighboring gene CG4672 gene product from transcript CG4672-RA Neighboring gene CG4573 gene product from transcript CG4573-RA Neighboring gene CG33158 gene product from transcript CG33158-RB Neighboring gene doublesex cognate 73A Neighboring gene argos

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Parry TJ, et al. Genes Dev, 2010 Sep 15. PMID 20801935.
    3. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034.
    4. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Storkebaum E, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19561293.
    5. Drosophila growth and development in the absence of dMyc and dMnt. Pierce SB, et al. Dev Biol, 2008 Mar 15. PMID 18241851.

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.
      Title: Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:65135 BioGRID:63563 RpL19    BioGRID  PubMed Two-hybrid 
    BioGRID:65135 BioGRID:64396 Zasp66    BioGRID  PubMed Two-hybrid 
    BioGRID:65135 BioGRID:78166 eIF-4B    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    tyrosine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    tyrosine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    tyrosine-tRNA ligase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    tyrosyl-tRNA aminoacylation NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG4561 gene product from transcript CG4561-RA
    Names
    Aats-tyr-PA
    CG4561-PA
    Tyrosyl-tRNA synthetase
    NP_648895.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      16410447..16412395, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140638.2 → NP_648895.1  Tyrosyl-tRNA synthetase [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV60
      Related
      FBpp0075168, FBtr0075410
      Conserved Domains (3) summary
      cd02799
      Location:365 – 466
      Blast Score: 412
      tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
      TIGR00234
      Location:10 – 332
      Blast Score: 413
      tyrS; tyrosyl-tRNA synthetase
      cd00805
      Location:35 – 322
      Blast Score: 699
      TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic HB892384.1 CBF71216.1
    genomic HB930974.1 CBG00381.1
    genomic HC966938.1 CBV03394.1
    genomic HB909529.1 CBF89222.1
    genomic HC988383.1 CBV13901.1
    genomic HC962349.1 CBV01149.1
    mRNA AY051662.1 AAK93086.1
    genomic HB904940.1 CBF84168.1
    genomic HC949793.1 CBU95105.1
    genomic AE014296.4 AAF49462.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV60.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content