atr ataxia telangiectasia and Rad3 related [Xenopus laevis] - Gene

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Summary

Official Symbol: atr
Official Full Name: ataxia telangiectasia and Rad3 related
Primary source: Xenbase:XB-GENE-1012725
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: XATR; frp1; mec1; sckl; sckl1

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11/Rad50/Nbs1 dependent recovery of collapsed replication forks.
Title: ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.
Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.
Title: CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.
Title: The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.
ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 and centrosome dependent spindle assembly.
Title: An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.
interaction of the 9-1-1 complex (Rad9-Hus1-Rad1) with the BRCT I-II region of TopBP1 is necessary for binding of ATR-ATRIP to the ATR-activating domain of TopBP1 and the ensuing activation of ATR
Title: The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 with ATR(ATM and Rad3-related).
Title: Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.
Cut5 plays a crucial role in the initial amplification step of the ATR-Chk1 signaling pathway at the stalled replication fork.
Title: The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.
ATRIP must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 effectively
Title: Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.
ATM and ATR phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts
Title: Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses.
Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP.
Title: TopBP1 activates the ATR-ATRIP complex.

Submit: New GeneRIF Correction See all (11)

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:99532	BioGRID:107426	CDC6	BioGRID	PubMed	Reconstituted Complex
BioGRID:99532	BioGRID:100831	cdc6	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:99532	BioGRID:98693	mcm2	BioGRID	PubMed	Biochemical Activity

General gene information

Homology

Homologs of the atr gene: The atr gene is conserved in human, chimpanzee, , dog, cow, mouse, chicken, and zebrafish.

Pathways from BioSystems

Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Fanconi anemia pathway, organism-specific biosystem (from KEGG)
Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
Fanconi anemia pathway, conserved biosystem (from KEGG)
Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

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General protein information

Preferred Names: serine/threonine-protein kinase atr

Names: serine/threonine-protein kinase atr; protein kinase; checkpoint kinase; ataxia telangiectasia and Rad3-related protein

NP_001082049.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088580.1 → NP_001082049.1 serine/threonine-protein kinase atr

Status: PROVISIONAL

Source sequence(s)

AY882989

UniProtKB/Swiss-Prot

Q9DE14

Conserved Domains (5) summary

cd00892
Location:2304 – 2578
Blast Score: 1233

PIKKc_ATR; ATR (Ataxia telangiectasia and Rad3-related), catalytic domain; The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...

cl06893
Location:1135 – 1240
Blast Score: 285

UME; UME (NUC010) domain

smart00146
Location:2335 – 2578
Blast Score: 761

PI3Kc; Phosphoinositide 3-kinase, catalytic domain

pfam02259
Location:1786 – 2104
Blast Score: 507

FAT; FAT domain

pfam02260
Location:2623 – 2655
Blast Score: 140

FATC; FATC domain