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    ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma [ Homo sapiens ]

    Gene ID: 398, updated on 11-May-2012
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    Summary

    Official Symbol
    ARHGDIGprovided by HGNC
    Official Full Name
    Rho GDP dissociation inhibitor (GDI) gammaprovided by HGNC
    Primary source
    HGNC:680
    Locus tag
    LA16c-314G4.1
    See related
    Ensembl:ENSG00000242173; HPRD:04163; MIM:602844; Vega:OTTHUMG00000064892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RHOGDI-3
    Summary
    The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
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    Genomic context

    Location :
    16p13.3
    Sequence :
    Chromosome: 16; NC_000016.9 (330606..333003)
    See ARHGDIG in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 3 Neighboring gene regulator of G-protein signaling 11 Neighboring gene protein disulfide isomerase family A, member 2 Neighboring gene axin 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug. PMID 21697133.
    2. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. Wooten EC, et al. PLoS One, 2010 Jan 21. PMID 20098615.
    3. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553.
    4. Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors. Dransart E, et al. J Biol Chem, 2005 Feb 11. PMID 15513926.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.
    2. analysis of inhibitory and shuttling functions of rhoGDI-3 and rhoGDI-1
      Title: Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001167.1 NP_942126.1 RAC1    BIND  PubMed Rac1 interacts with RhoGDI. 
    Q99819 P60953 CDC42    HPRD  PubMed  
    Q99819 P63000 RAC1    HPRD  PubMed  
    Q99819 P61586 RHOA    HPRD  PubMed  
    Q99819 P62745 RHOB    HPRD  PubMed  
    Q99819 P84095 RHOG    HPRD  PubMed  
    Q99819 Q15669 RHOH    HPRD  PubMed  
    BioGRID:106891 BioGRID:107433 CDC42    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106891 BioGRID:106880 RHOA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106891 BioGRID:106881 RHOB    BioGRID  PubMed Two-hybrid 
    BioGRID:106891 BioGRID:106884 RHOG    BioGRID  PubMed Two-hybrid 
    BioGRID:106891 BioGRID:106892 RHOH    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: PDIA2

    Homology

    Pathways from BioSystems

    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Rho GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic membrane-bounded vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    rho GDP-dissociation inhibitor 3
    Names
    rho GDP-dissociation inhibitor 3
    rho GDI 3
    RhoGDI gamma
    rho-GDI gamma
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001176.3 → NP_001167.2  rho GDP-dissociation inhibitor 3

      Status: VALIDATED

      Source sequence(s)
      BC047699, BM662457, Z69667
      Consensus CDS
      CCDS10404.1
      UniProtKB/TrEMBL
      F1T0H7
      UniProtKB/Swiss-Prot
      Q99819
      Related
      ENSP00000219409, OTTHUMP00000067352, ENST00000219409, OTTHUMT00000139321
      Conserved Domains (1) summary
      pfam02115
      Location:36 – 222
      Blast Score: 779
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      330606..333003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      241938..251249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE006463.1 AAK61222.1
    genomic AF080237.1 AAC72354.1
    genomic CH471112.2 EAW85837.1
    genomic Z69667.1 CAI95584.1
      CAI95585.1
      CAM26353.1
    mRNA AB593111.1 BAJ84051.1
    mRNA AF498928.1 AAM21076.1
    mRNA BC047699.1 AAH47699.1
    mRNA BM662457.1 None
    mRNA BU732723.1 None
    mRNA U82532.1 AAC33138.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4TT68 GenPept UniProtKB/TrEMBL:Q4TT68
    Q99819.2 GenPept UniProtKB/Swiss-Prot:Q99819
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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