My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    MED10 Mediator complex subunit 10 [ Drosophila melanogaster ]

    Gene ID: 39777, updated on 10-May-2012
    Help top of page

    Summary

    Official Symbol
    MED10provided by Flybase
    Official Full Name
    Mediator complex subunit 10provided by Flybase
    Primary source
    FLYBASE:FBgn0036581
    Locus tag
    Dmel_CG5057
    Gene type
    protein coding
    RNA name
    mediator complex subunit 10
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD24044; CG5057; dMED10; Dmel\CG5057; dTRAP15; l(3)72Ds; med10; Med10; Nut2
    Help top of page

    Genomic context

    Location :
    72D10-72D10
    Sequence :
    Chromosome: 3L; NT_037436.3 (16225129..16225836)
    See MED10 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene lethal (3) 72Dn Neighboring gene CG5027 gene product from transcript CG5027-RA Neighboring gene CG13072 gene product from transcript CG13072-RA Neighboring gene lethal (3) 72Do Neighboring gene lethal (3) 72Dp Neighboring gene lethal (3) 72Dr

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143.
    3. Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. Terriente-Félix A, et al. Genetics, 2010 Jun. PMID 20233856.
    4. Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. Ranade SS, et al. Dev Biol, 2008 Mar 15. PMID 18241855.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_648849.2 NP_648094.1 MED4    BIND  PubMed Nut2 interacts with Trap36 
    BioGRID:65085 BioGRID:58653 Bap60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:63895 CG11505    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:66158 CG11672    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:67667 CG13838    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:61499 CG17002    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:60537 CG18284    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:65937 CG2017    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:59881 CG3008    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:60536 CG31872    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:60444 CG34159    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:67409 CG5191    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:66653 CG6225    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:64355 CG7185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:62106 Cam    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:59813 Cep97    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:64104 DnaJ-1    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:57914 HLH4C    BioGRID  PubMed Two-hybrid 
    BioGRID:65085 BioGRID:65323 MED11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:63628 MED14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:59479 MED15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:63152 MED16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:67196 MED17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:57686 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:68741 MED20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:63250 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:65902 MED27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:63633 MED30    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:64242 MED4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:69231 MED6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:66432 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:62960 MED8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:62596 Psi    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:67198 Ssdp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:71878 boca    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:58490 dsh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:59468 ebi    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:69121 enc    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:69950 ix    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:65085 BioGRID:66996 mor    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65085 BioGRID:64891 ptip    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Homology

    • Homologs of the MED10 gene: The MED10 gene is conserved in human, chimpanzee, , dog, cow, mouse, chicken, zebrafish, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    RNA polymerase II transcription cofactor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    RNA polymerase II transcription cofactor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    CG5057 gene product from transcript CG5057-RB
    Names
    CG5057-PB
    MED10-PB
    mediator
    mediator complex subunit 10
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      16225129..16225836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140592.3 → NP_648849.3  mediator complex subunit 10 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GYU7
      Related
      FBpp0290696, FBtr0301481
      Conserved Domains (1) summary
      pfam09748
      Location:8 – 128
      Blast Score: 405
      Med10; Transcription factor subunit Med10 of Mediator complex
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAF49523.3
    mRNA AY005465.1 AAF97815.1
    mRNA AY118450.1 AAM48479.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GYU7.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

      Supplemental Content