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    FGF2 fibroblast growth factor 2 (basic) [ Sus scrofa (pig) ]

    Gene ID: 397643, updated on 11-May-2013
    Gene symbol
    FGF2
    Gene description
    fibroblast growth factor 2 (basic)
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Location :
    chromosome: 8
    Sequence :
    Chromosome: 8; NC_010450.3 (108489471..108545489, complement)
    See FGF2 in MapViewer

    Chromosome 8 - NC_010450.3Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 5 Neighboring gene nucleoside diphosphate-linked moiety X motif 6-like Neighboring gene interleukin 21 Neighboring gene interleukin 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway. Han L, et al. Cardiovasc Pathol, 2012 Sep-Oct. PMID 22227366.
    2. NUDT6, the FGF-2's antisense gene, showed associations with fat deposition related traits in pigs. Sun L, et al. Mol Biol Rep, 2012 Apr. PMID 21786158.
    3. Shear stress induces the release of an endothelial elastase: role in integrin α(v)β(3)-mediated FGF-2 release. Hennig T, et al. J Vasc Res, 2011. PMID 21691119.
    4. mRNA and protein expression of FGF-1, FGF-2 and their receptors in the porcine umbilical cord during pregnancy. Chrusciel M, et al. Folia Histochem Cytobiol, 2010 Dec. PMID 21478100.
    5. Expression and possible role of fibroblast growth factor family members in porcine antral follicles during final maturation. Schams D, et al. Reproduction, 2009 Jul. PMID 19380425.

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway.
      Title: Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway.
    2. The overlapping relationships of 3'UTR ends between NUDT6 and FGF-2 genes, were analyzed.
      Title: NUDT6, the FGF-2's antisense gene, showed associations with fat deposition related traits in pigs.
    3. FGF2 in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.
      Title: Expression and possible role of fibroblast growth factor family members in porcine antral follicles during final maturation.
    4. By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 from endothelial cells.
      Title: Shear stress induces the release of an endothelial elastase: role in integrin α(v)β(3)-mediated FGF-2 release.
    5. qPCR analysis demonstrated an increase in FGF-2 mRNA levels beginning on day 75 and on day 114 of pregnancy.
      Title: mRNA and protein expression of FGF-1, FGF-2 and their receptors in the porcine umbilical cord during pregnancy.
    6. FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1)-mediated myofibroblast activation
      Title: Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells.
    7. upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
      Title: Expression of FGF2 and TGFalpha and testis morphology during testicular hypertrophy subsequent to hemicastration in the neonatal boar.
    8. FGF2 activates FGFR which then represses the fibroblast activation of valvular interstitial cells.
      Title: Material-based regulation of the myofibroblast phenotype.
    Submit: New GeneRIF Correction
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    Markers

    Names
    fibroblast growth factor 2 (basic)

    RefSeqs of Annotated Genomes: Build 4.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa10.2 Primary Assembly

    Genomic

    1. NC_010450.3

      Range
      108489471..108545489, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003129213.3 → XP_003129261.3  

      Conserved Domains (1) summary
      cd00058
      Location:234 – 325
      Blast Score: 283
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    Nucleotide Protein
    Heading Accession and Version
    genomic FP102941.2 (41382..55375) None
    mRNA AJ577089.1 CAE11791.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

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      • BioProjects
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      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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