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hzg herzog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39748, updated on 11-Apr-2024

Summary

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Official Symbol
hzgprovided by FlyBase
Official Full Name
herzogprovided by FlyBase
Primary source
FLYBASE:FBgn0036556
Locus tag
Dmel_CG5830
See related
AllianceGenome:FB:FBgn0036556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
24664944; CG5830; Dmel\CG5830
Summary
Enables phosphoprotein phosphatase activity. Involved in positive regulation of embryonic development and protein dephosphorylation. Located in plasma membrane. Is expressed in adult brain cell body rind; adult head; and adult mushroom body. Orthologous to several human genes including CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
72C1-72C2; 3-43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15992669..16004736, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15985769..15997836, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45446 Neighboring gene DNA polymerase delta subunit 1 Neighboring gene Huntingtin-interacting protein 14 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene mind bomb 1 Neighboring gene long non-coding RNA:CR43950 Neighboring gene long non-coding RNA:CR45998

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
herzog
Names
CG5830-PA
CG5830-PB
hzg-PA
hzg-PB
NP_001261912.1
NP_648825.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15992669..16004736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140568.3 → NP_648825.1  herzog, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUX0
    Related
    FBpp0075276
    Conserved Domains (2) summary
    COG5190
    Location:78 → 253
    FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]
    TIGR02251
    Location:89 → 247
    HIF-SF_euk; Dullard-like phosphatase domain

  2. NM_001274983.2 → NP_001261912.1  herzog, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261912.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PFN0, Q7YU53, Q9VUX0
    Conserved Domains (1) summary
    TIGR02251
    Location:112 → 270
    HIF-SF_euk; Dullard-like phosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFN0.1 M9PFN0

Gene LinkOut

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