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ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Sus scrofa (pig) ]

Gene ID: 397445, updated on 5-Mar-2024

Summary

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Official Symbol
ROCK2provided by VGNC
Official Full Name
Rho associated coiled-coil containing protein kinase 2provided by VGNC
Primary source
VGNC:VGNC:110710
See related
Ensembl:ENSSSCG00000008629
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
ROCK-II
Expression
Ubiquitous expression in psoas major muscle (RPKM 34.6), longissimus dorsi muscle (RPKM 21.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
36
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (125353063..125493368)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (134221182..134297878, complement)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene E2F transcription factor 6 Neighboring gene AP-3 complex subunit sigma-1 pseudogene Neighboring gene solute carrier family 66 member 3 Neighboring gene chromosome 3 C2orf50 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Distinct roles of ROCK1 and ROCK2 during development of porcine preimplantation embryos. Zhang JY, et al. Reproduction, 2014 Jul. PMID 24803490
  2. Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms. Matsumoto Y, et al. Arterioscler Thromb Vasc Biol, 2004 Jan. PMID 14592842
  3. Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Saito T, et al. Circulation, 2013 Jan 1. PMID 23172836
  4. Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. Huk DJ, et al. Arterioscler Thromb Vasc Biol, 2016 Feb. PMID 26634652, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that ROCK1 and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
    Title: Distinct roles of ROCK1 and ROCK2 during development of porcine preimplantation embryos.
  2. ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.
    Title: Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.
  3. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
    Title: Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho-associated protein kinase 2
Names
Rho kinase 2
Rho-associated protein kinase 2
Rho-associated, coiled-coil-containing protein kinase II
Rho-kinase alpha
p164 ROCK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    125353063..125493368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021087837.1 → XP_020943496.1  rho-associated protein kinase 2 isoform X8

    UniProtKB/Swiss-Prot
    F1SCR1, M3TYT0
    UniProtKB/TrEMBL
    A0A8D1IAC1
    Related
    ENSSSCP00000079036.1, ENSSSCT00000093479.1
    Conserved Domains (4) summary
    cd00029
    Location:1261 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1151 → 1257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021087833.1 → XP_020943492.1  rho-associated protein kinase 2 isoform X4

    UniProtKB/TrEMBL
    A0A4X1U8L4, A0A8D0XAF1
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1318 → 1364
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1208 → 1314
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_021087831.1 → XP_020943490.1  rho-associated protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A4X1U8L4, A0A4X1UB34
    Related
    ENSSSCP00000009198.4, ENSSSCT00000009440.4
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1318 → 1364
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1208 → 1314
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_013987936.2 → XP_013843390.2  rho-associated protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A4X1U8L4
    Related
    ENSSSCP00000064031.2, ENSSSCT00000090755.2
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1320 → 1366
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1210 → 1316
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_021087832.1 → XP_020943491.1  rho-associated protein kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A4X1U8L4
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1320 → 1366
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1210 → 1316
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  6. XM_021087834.1 → XP_020943493.1  rho-associated protein kinase 2 isoform X5

    UniProtKB/TrEMBL
    A0A4X1U8L4
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1320 → 1366
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1210 → 1316
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  7. XM_021087835.1 → XP_020943494.1  rho-associated protein kinase 2 isoform X6

    UniProtKB/TrEMBL
    A0A8D1IAC1
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1261 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1151 → 1257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

  8. XM_021087836.1 → XP_020943495.1  rho-associated protein kinase 2 isoform X7

    UniProtKB/TrEMBL
    A0A8D1IAC1
    Conserved Domains (5) summary
    cd11638
    Location:505 → 571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:1261 → 1307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:1151 → 1257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39 → 417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:437 → 1101
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_002342861.1 RNA Sequence

  2. XR_002342860.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M3TYT0.1 GenPept UniProtKB/Swiss-Prot:M3TYT0

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