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ACACA acetyl-CoA carboxylase alpha [ Sus scrofa (pig) ]

Gene ID: 397324, updated on 5-Mar-2024

Summary

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Official Symbol
ACACAprovided by VGNC
Official Full Name
acetyl-CoA carboxylase alphaprovided by VGNC
Primary source
VGNC:VGNC:84997
See related
Ensembl:ENSSSCG00000017694
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in subcutaneous adipose (RPKM 14.4), ovary (RPKM 9.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
60
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (38580916..38875067, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (40200228..40401426, complement)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene LIM homeobox 1 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene chromosome 12 C17orf78 homolog Neighboring gene transcriptional adaptor 2A Neighboring gene dual specificity phosphatase 14 Neighboring gene synergin gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Alternative splicing at exon 28 of the acetyl-coenzyme A carboxylase alpha gene in adult pigs and embryos. Gallardo D, et al. Anim Genet, 2008 Apr. PMID 18318787
  2. The ACACA and SREBF1 genes are promising markers for pig carcass and performance traits, but not for fatty acid content in the longissimus dorsi muscle and adipose tissue. Stachowiak M, et al. Meat Sci, 2013 Sep. PMID 23657179
  3. QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes. Muñoz G, et al. Anim Genet, 2007 Dec. PMID 18052940

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits.
    Title: The ACACA and SREBF1 genes are promising markers for pig carcass and performance traits, but not for fatty acid content in the longissimus dorsi muscle and adipose tissue.
  2. Alternative splicing of exon 28, which has been consistently described in human, rat and sheep has now been found in pigs.
    Title: Alternative splicing at exon 28 of the acetyl-coenzyme A carboxylase alpha gene in adult pigs and embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
acetyl-CoA carboxylase 1
Names
acetyl-Coenzyme A carboxylase alpha
NP_001107741.1
XP_020921886.1
XP_020921887.1
XP_020921888.1
XP_020921889.1
XP_020921890.1
XP_020921892.1
XP_020921893.1
XP_020921894.1
XP_020921895.1
XP_020921896.1
XP_020921897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114269.1 → NP_001107741.1  acetyl-CoA carboxylase 1

    See identical proteins and their annotated locations for NP_001107741.1

    Status: PROVISIONAL

    Source sequence(s)
    EU168399
    UniProtKB/TrEMBL
    A0A287BBE6, B0LJD0
    Conserved Domains (7) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:289 → 470
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    38580916..38875067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021066228.1 → XP_020921887.1  acetyl-CoA carboxylase 1 isoform X2

    UniProtKB/TrEMBL
    A0A480I1V1, A0A8D1AIK9, A0A8D1ZHV3
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1661 → 2209
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1554
    ACC_central; Acetyl-CoA carboxylase, central region

  2. XM_021066229.1 → XP_020921888.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/TrEMBL
    A0A480IPW3, A0A480V8D5
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  3. XM_021066236.1 → XP_020921895.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A0B8RW56, A0A287BBE6, A0A4X1T021, A0A8D0J6C2, D2D0D8, F1S1B5
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  4. XM_021066235.1 → XP_020921894.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A0B8RW56, A0A287BBE6, A0A4X1T021, A0A8D0J6C2, D2D0D8, F1S1B5
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  5. XM_021066227.1 → XP_020921886.1  acetyl-CoA carboxylase 1 isoform X1

    UniProtKB/TrEMBL
    A0A4X1T1I8, A0A8D0JA01
    Conserved Domains (4) summary
    COG0439
    Location:149 → 651
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:784 → 849
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1700 → 2248
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:851 → 1593
    ACC_central; Acetyl-CoA carboxylase, central region

  6. XM_021066230.1 → XP_020921889.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A0B8RW56, A0A287BBE6, A0A4X1T021, A0A8D0J6C2, D2D0D8, F1S1B5
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  7. XM_021066233.1 → XP_020921892.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A0B8RW56, A0A287BBE6, A0A4X1T021, A0A8D0J6C2, D2D0D8, F1S1B5
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  8. XM_021066237.1 → XP_020921896.1  acetyl-CoA carboxylase 1 isoform X2

    UniProtKB/TrEMBL
    A0A480I1V1, A0A8D1AIK9, A0A8D1ZHV3
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1661 → 2209
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1554
    ACC_central; Acetyl-CoA carboxylase, central region

  9. XM_021066234.1 → XP_020921893.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A0B8RW56, A0A287BBE6, A0A4X1T021, A0A8D0J6C2, D2D0D8, F1S1B5
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  10. XM_021066231.1 → XP_020921890.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A0B8RW56, A0A287BBE6, A0A4X1T021, A0A8D0J6C2, D2D0D8, F1S1B5
    Related
    ENSSSCP00000053665.3, ENSSSCT00000042467.3
    Conserved Domains (4) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region

  11. XM_021066238.1 → XP_020921897.1  acetyl-CoA carboxylase 1 isoform X5

    UniProtKB/TrEMBL
    A0A4X1T225
    Conserved Domains (4) summary
    COG0439
    Location:59 → 561
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:694 → 759
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1610 → 2158
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:761 → 1503
    ACC_central; Acetyl-CoA carboxylase, central region
Nucleotide Protein Strain
Heading Accession and Version

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