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    VEGFA vascular endothelial growth factor A [ Sus scrofa (pig) ]

    Gene ID: 397157, updated on 15-Jun-2013
    Gene symbol
    VEGFA
    Gene description
    vascular endothelial growth factor A
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Also known as
    VEGF
    Location :
    7; 7
    Sequence :
    Chromosome: 7; NC_010449.4 (44460526..44473797)
    See VEGFA in MapViewer

    Chromosome 7 - NC_010449.4Genomic Context describing neighboring genes Neighboring gene GTP-binding protein 2-like Neighboring gene vascular endothelial growth factor A-like Neighboring gene 39S ribosomal protein L14, mitochondrial-like Neighboring gene transmembrane protein 63B

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis. Zhang C, et al. Sci Rep, 2012. PMID 22970342.
    2. Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart. Tao Z, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245320.
    3. Expression of the vascular endothelial growth factor (VEGF-A) and its receptors in the umbilical cord in the course of pregnancy in the pig. Chruściel M, et al. Reprod Domest Anim, 2011 Jun. PMID 20825582.
    4. Expression and localization of angiogenic growth factors in developing porcine mesonephric glomeruli. De Spiegelaere W, et al. J Histochem Cytochem, 2010 Dec. PMID 20713984.
    5. Characterization of neural stem/progenitor cells expressing VEGF and its receptors in the subventricular zone of newborn piglet brain. Ara J, et al. Neurochem Res, 2010 Sep. PMID 20552272.

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
      Title: Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis.
    2. data shows that members of the VEGF-VEGFR system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
      Title: Expression of the vascular endothelial growth factor (VEGF-A) and its receptors in the umbilical cord in the course of pregnancy in the pig.
    3. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
      Title: Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart.
    4. The mRNA for VEGFA was expressed in early developing and in maturing glomeruli.
      Title: Expression and localization of angiogenic growth factors in developing porcine mesonephric glomeruli.
    5. Data show that subventricular zone neural stem cells express VEGF and all VEGF splice variants, VEGFR1, VEGFR2 and Neuropilin-1 and -2 mRNAs.
      Title: Characterization of neural stem/progenitor cells expressing VEGF and its receptors in the subventricular zone of newborn piglet brain.
    6. Interaction of soluble factors in plasma possibly generated during PICSO are not responsible for upregulation of HO-1 and VEGF mRNA.
      Title: Soluble plasma factors derived from ischemic, PICSO-treated, porcine hearts are not responsible for HO-1 and VEGF mRNA expression in endothelial cells.
    7. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.
      Title: Increased shear stress with upregulation of VEGF-A and its receptors and MMP-2, MMP-9, and TIMP-1 in venous stenosis of hemodialysis grafts.
    8. VEGF-A family members are probably involved in appropriate preparation of endometrium for implantation and in vascular events during implantation in pigs.
      Title: Expression of the vascular endothelial growth factor-receptor system in the porcine endometrium throughout the estrous cycle and early pregnancy.
    9. Contrast media did not affect bone marrow cell viability/VEGF secretion.
      Title: Effects of contrast media on porcine bone marrow-derived mononuclear cells and calf myoblast viability and secretion of VEGF and MCP-1.
    10. VEGF/Flk-1/Flt-1 system is activated during myocardial ischemia reperfusion injury.
      Title: Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury.
    Submit: New GeneRIF Correction See all (19)

    Markers

    Genotypes

    Homology

    Preferred Names
    vascular endothelial growth factor A
    Names
    vascular endothelial growth factor A
    VPF
    VEGF-A
    vascular permeability factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214084.1 → NP_999249.1  vascular endothelial growth factor A precursor

      Status: PROVISIONAL

      Source sequence(s)
      AF318502
      UniProtKB/Swiss-Prot
      P49151
      Conserved Domains (1) summary
      cd00135
      Location:49 – 132
      Blast Score: 263
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

    RefSeqs of Annotated Genomes: Build 4.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa10.2 Primary Assembly

    Genomic

    1. NC_010449.4 Reference Sscrofa10.2 Primary Assembly

      Range
      44460526..44473797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic CT009664.17 (92796..106067) None
    mRNA AF041084.1 AAB96780.1
    mRNA AF318502.1 AAG33064.1
    mRNA AF461807.1 AAL85286.1 Yorkshire
    mRNA AY072734.1 AAL68393.1 Yorkshire
    mRNA AY616676.1 AAT38876.1
    mRNA EU714324.1 ACF37105.1
    mRNA JF831364.1 AEP25617.1 Banna Mini-pig inbred line (BMI)
    mRNA X81380.1 CAA57143.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49151.1 GenPept UniProtKB/Swiss-Prot:P49151

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous

        Supplemental Content

        Table of contents

        Related information

        • BioProjects
          BioProjects related to a gene
        • BioSystems
          BioSystems
        • Conserved Domains
          Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
        • Full text in PMC
          PMC links
        • Full text in PMC_nucleotide
          Full text in PubMedCentral identified from shared sequence links
        • Genome
          Genome records having the gene annotated on corresponding genomic reference sequence.
        • GEO Profiles
          Related GEO
        • Map Viewer
          These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
        • Nucleotide
          Link to related Nucleotide entry
        • Probe
          Related Probe entry
        • Protein
          Link to related protein entry
        • PubChem Compound
          PubChem Compounds
        • PubChem Substance
          PubChem Substances
        • PubMed
          Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
        • PubMed (GeneRIF)
          GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
        • PubMed(nucleotide/PMC)
          Citations in PubMed identified from shared sequence and PMC links.
        • RefSeq Proteins
          Link to Protein RefSeqs
        • RefSeq RNAs
          Link to Nucleotide RefSeq RNAs
        • SNP
          Related SNP records
        • SNP: GeneView
          SNPs linked from GeneView
        • Taxonomy
          Link to related taxonomy entry
        • UniGene
          Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
        • UniSTS
          Related UniSTS records

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