ARHGDIB Rho GDP dissociation inhibitor (GDI) beta [Homo sapiens] - Gene

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Summary

Official Symbol: ARHGDIBprovided by HGNC
Official Full Name: Rho GDP dissociation inhibitor (GDI) betaprovided by HGNC
Primary source: HGNC:679
See related: Ensembl:ENSG00000111348; HPRD:04162; MIM:602843; Vega:OTTHUMG00000168742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2
Summary: Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

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Genomic context

Location :: 12p12.3

Sequence :: Chromosome: 12; NC_000012.11 (15094950..15114562, complement)

See ARHGDIB in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of RhoGDI2 correlates with tumor progression in colorectal carcinoma.
Title: Overexpression of RhoGDI2 correlates with tumor progression and poor prognosis in colorectal carcinoma.
activation of the Src family members and downstream signalling proteins are associated with a good prognosis in transitional cell carcinoma of the bladder, and activated Src has a positive relationship with RhoGD12.
Title: The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder.
PLCgamma plays a key role in RhoGDI2-mediated cisplatin resistance and cell invasion in gastric cancer cells.
Title: PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer.
identification of LyGDI as a binding partner of SHIP, associating inducibly with the SHIP/Grb2/Shc complex
Title: LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis.
This study has revealed that Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and the HSP70/90 organizing protein have a critical role to play in resistance to cyclin-depedent kinases inhibitor.
Title: Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application.
RhoGDI2 is likely to be involved in lung tumor malignancy and metastasis.
Title: Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis.
High LyGDI serum levels are associated with ovarian cancer.
Title: LyGDI is a promising biomarker for ovarian cancer.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
RhoGDI2 is associated with c-Src in bladder tumors, where the expression of both is diminished as a function of stage. c-Src binds to and phosphorylates RhoGDI2 resulting in enhanced metastasis suppressive potency. Review.
Title: Pathways of metastasis suppression in bladder cancer.
Results show that the established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIbeta.
Title: Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.

Submit: New GeneRIF Correction See all (24)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P52566	P42574	CASP3	HPRD	PubMed
P52566	P60953	CDC42	HPRD	PubMed
P52566	P15311	EZR	HPRD	PubMed
P52566	P63000	RAC1	HPRD	PubMed
P52566	P15153	RAC2	HPRD	PubMed
P52566	P61586	RHOA	HPRD	PubMed
P52566	Q15669	RHOH	HPRD	PubMed
P52566	P15498	VAV1	HPRD	PubMed
BioGRID:106890	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106890	BioGRID:121890	KLHL12	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106890	BioGRID:111817	RAC1	BioGRID	PubMed	Two-hybrid
BioGRID:106890	BioGRID:111818	RAC2	BioGRID	PubMed	Co-crystal Structure
BioGRID:106890	BioGRID:111819	RAC3	BioGRID	PubMed	Two-hybrid
BioGRID:106890	BioGRID:106892	RHOH	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106890	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106890	BioGRID:119616	UFM1	BioGRID	PubMed	Two-hybrid
BioGRID:106890	BioGRID:113252	VAV1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
GTPase activator activity	IEA Inferred from Electronic Annotation more info
Rho GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
cellular component movement	TAS Traceable Author Statement more info	PubMed
immune response	TAS Traceable Author Statement more info	PubMed
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
negative regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytoplasmic membrane-bounded vesicle	TAS Traceable Author Statement more info	PubMed
cytoskeleton	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: rho GDP-dissociation inhibitor 2

Names: rho GDP-dissociation inhibitor 2; Rho GDI 2; rho-GDI beta

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001175.4 → NP_001166.3 rho GDP-dissociation inhibitor 2

Status: VALIDATED

Source sequence(s)

AA143425, AF498927, BC009200, L20688

Consensus CDS

CCDS8671.1

UniProtKB/Swiss-Prot

P52566

Related

ENSP00000228945, OTTHUMP00000239340, ENST00000228945, OTTHUMT00000400871

Conserved Domains (1) summary

pfam02115
Location:1 – 198
Blast Score: 797

Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

15094950..15114562, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

14864323..14883946, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007655.1 (152739..172351)	None
genomic	CH471094.1	EAW96336.1
		EAW96337.1
		EAW96338.1
		EAW96339.1
		EAW96340.1
		EAW96341.1
		EAW96342.1
genomic	FB571118.1	CAR95110.1
genomic	FB668249.1	CAS92768.1
mRNA	AA143425.1	None
mRNA	AB451315.1	BAG70129.1
mRNA	AB451445.1	BAG70259.1
mRNA	AF498927.1	AAM21075.1
mRNA	AK311807.1	BAG34750.1
mRNA	BC009200.2	AAH09200.1
mRNA	L07916.1	None
mRNA	L20688.1	AAA59539.1
mRNA	X69549.1	CAA49280.1
other-genetic	DQ893303.2	ABM84229.1
other-genetic	DQ896476.2	ABM87475.1