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    MAPK8 mitogen-activated protein kinase 8 [ Sus scrofa (pig) ]

    Gene ID: 396610, updated on 15-Jun-2013
    Gene symbol
    MAPK8
    Gene description
    mitogen-activated protein kinase 8
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Also known as
    JNK; JNK1
    Location :
    chromosome: 14
    Sequence :
    Chromosome: 14; NC_010456.4 (96757349..96800479)
    See MAPK8 in MapViewer

    Chromosome 14 - NC_010456.4Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain-containing protein 2-like Neighboring gene FERM and PDZ domain containing 2 Neighboring gene rho GTPase-activating protein 22-like Neighboring gene mitogen-activated protein kinase 8-like

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production. Lee YJ, et al. Virology, 2012 Jun 5. PMID 22424736.
    2. Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus. Gao W, et al. PLoS One, 2012. PMID 22279582.
    3. Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Gesslein B, et al. Mol Vis, 2010 Mar 10. PMID 20300568.
    4. The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes. Petrová I, et al. J Reprod Dev, 2009 Feb. PMID 19023183.
    5. Identification of ERK and JNK as signaling mediators on protein kinase C activation in cultured granulosa cells. Sriraman V, et al. Mol Cell Endocrinol, 2008 Nov 6. PMID 18694803.

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1/2 dependent.
      Title: Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus.
    2. These data suggest that the p38 and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
      Title: Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production.
    3. JNK plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
      Title: The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes.
    4. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
      Title: Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion.
    5. based on the data, we can conclude that JNK plays an active role in fragmentation of pig oocytes and that p38 MAPK is not involved in this process
      Title: The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes.
    6. PP2A and AIP1 cooperatively induce activation of ASK1-JNK signaling and vascular endothelial cell apoptosis.
      Title: AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.
    7. Phorbol 12-myristate 13-acetate activation of ERK and JNK signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
      Title: Identification of ERK and JNK as signaling mediators on protein kinase C activation in cultured granulosa cells.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Names
    mitogen-activated protein kinase 8
    janus kinase 1

    RefSeqs of Annotated Genomes: Build 4.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa10.2 Primary Assembly

    Genomic

    1. NC_010456.4

      Range
      96757349..96800479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001929166.3 → XP_001929201.3  

      Conserved Domains (2) summary
      cd07850
      Location:9 – 360
      Blast Score: 2072
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
      smart00220
      Location:26 – 321
      Blast Score: 672
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. XM_003359272.1 → XP_003359320.1  

      UniProtKB/TrEMBL
      F1SEL1
      Conserved Domains (2) summary
      cd07850
      Location:9 – 360
      Blast Score: 2054
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
      smart00220
      Location:26 – 321
      Blast Score: 673
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    genomic CT737310.5 None
    genomic CU468448.2 (131993..173739) None
    mRNA AJ583707.1 CAE47554.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
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      Supplemental Content

      Table of contents

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      • BioProjects
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      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
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      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
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        SNPs linked from GeneView
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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