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PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Gallus gallus (chicken) ]

Gene ID: 396534, updated on 3-Apr-2024

Summary

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Official Symbol
PAICSprovided by CGNC
Official Full Name
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthaseprovided by CGNC
Primary source
CGNC:10274
See related
Ensembl:ENSGALG00010014847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
AS; AIRC
Orthologs
human all
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Genomic context

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See PAICS in Genome Data Viewer
Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (64253806..64288832, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (64237015..64271578, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 9B (putative) Neighboring gene LON peptidase N-terminal domain and ring finger 1 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene centrosomal protein 135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants. Chen ZD, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 1691501, Free PMC Article
  2. Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter. Gavalas A, et al. Mol Cell Biol, 1993 Aug. PMID 8336716, Free PMC Article
  3. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
multifunctional protein ADE2
Names
AIR carboxylase domain
AIR carboxylase-SAICAR synthetase
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
NP_990855.1
XP_015140911.1
XP_015140912.1
XP_040554687.1
XP_040554689.1
XP_040554690.1
XP_040554691.1
XP_040554692.1
XP_046771562.1
XP_046771563.1
XP_046771564.1
XP_046771565.1
XP_046771566.1
XP_046771567.1
XP_046771568.1
XP_046771569.1
XP_046771570.1
XP_046795899.1
XP_046795901.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205524.3 → NP_990855.1  multifunctional protein ADE2

    See identical proteins and their annotated locations for NP_990855.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P38024, P87465
    UniProtKB/TrEMBL
    A7UEA7
    Related
    ENSGALP00010020724.1, ENSGALT00010035739.1
    Conserved Domains (2) summary
    cd01416
    Location:8 → 259
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:269 → 422
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    64253806..64288832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015285425.4 → XP_015140911.1  multifunctional protein ADE2 isoform X6

    UniProtKB/TrEMBL
    A0A1D5PH07, A0A8V0YWS3
    Related
    ENSGALP00010020741.1, ENSGALT00010035768.1
    Conserved Domains (3) summary
    cd01416
    Location:419 → 670
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:680 → 833
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    pfam13837
    Location:205 → 291
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  2. XM_046939943.1 → XP_046795899.1  multifunctional protein ADE2 isoform X4

  3. XM_040698755.2 → XP_040554689.1  multifunctional protein ADE2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3A5F2, A0A8V0YWS3
    Related
    ENSGALP00010020747.1, ENSGALT00010035779.1
    Conserved Domains (3) summary
    cd01416
    Location:595 → 846
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:856 → 1009
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:382 → 446
    GT1; myb-like, SANT family

  4. XM_040698757.2 → XP_040554691.1  multifunctional protein ADE2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2U811, A0A8V0YWS3
    Related
    ENSGALP00010020742.1, ENSGALT00010035769.1
    Conserved Domains (3) summary
    cd01416
    Location:448 → 699
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:709 → 862
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:235 → 299
    GT1; myb-like, SANT family

  5. XM_040698756.2 → XP_040554690.1  multifunctional protein ADE2 isoform X3

    UniProtKB/TrEMBL
    A0A1D5P4C5, A0A8V0YWS3
    Related
    ENSGALP00010020752.1, ENSGALT00010035788.1
    Conserved Domains (3) summary
    cd01416
    Location:594 → 845
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:855 → 1008
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:381 → 445
    GT1; myb-like, SANT family

  6. XM_040698753.2 → XP_040554687.1  multifunctional protein ADE2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YWS3
    Conserved Domains (3) summary
    cd01416
    Location:624 → 875
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:885 → 1038
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:411 → 475
    GT1; myb-like, SANT family

  7. XM_040698758.2 → XP_040554692.1  multifunctional protein ADE2 isoform X7

    UniProtKB/Swiss-Prot
    P38024, P87465
    UniProtKB/TrEMBL
    A7UEA7
    Conserved Domains (2) summary
    cd01416
    Location:8 → 259
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:269 → 422
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  8. XM_015285426.4 → XP_015140912.1  multifunctional protein ADE2 isoform X7

    UniProtKB/Swiss-Prot
    P38024, P87465
    UniProtKB/TrEMBL
    A7UEA7
    Conserved Domains (2) summary
    cd01416
    Location:8 → 259
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:269 → 422
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  9. XM_046939945.1 → XP_046795901.1  multifunctional protein ADE2 isoform X7

    UniProtKB/Swiss-Prot
    P38024, P87465

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    64237015..64271578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915611.1 → XP_046771567.1  multifunctional protein ADE2 isoform X6

    UniProtKB/TrEMBL
    A0A1D5PH07

  2. XM_046915609.1 → XP_046771565.1  multifunctional protein ADE2 isoform X4

  3. XM_046915607.1 → XP_046771563.1  multifunctional protein ADE2 isoform X2

  4. XM_046915610.1 → XP_046771566.1  multifunctional protein ADE2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2U811

  5. XM_046915608.1 → XP_046771564.1  multifunctional protein ADE2 isoform X3

  6. XM_046915606.1 → XP_046771562.1  multifunctional protein ADE2 isoform X1

  7. XM_046915613.1 → XP_046771569.1  multifunctional protein ADE2 isoform X7

    UniProtKB/Swiss-Prot
    P38024, P87465

  8. XM_046915612.1 → XP_046771568.1  multifunctional protein ADE2 isoform X7

    UniProtKB/Swiss-Prot
    P38024, P87465

  9. XM_046915614.1 → XP_046771570.1  multifunctional protein ADE2 isoform X7

    UniProtKB/Swiss-Prot
    P38024, P87465
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38024.1 GenPept UniProtKB/Swiss-Prot:P38024

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