LGALS7 lectin, galactoside-binding, soluble, 7 [Homo sapiens] - Gene

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Summary

Official Symbol: LGALS7provided by HGNC
Official Full Name: lectin, galactoside-binding, soluble, 7provided by HGNC
Primary source: HGNC:6568
See related: Ensembl:ENSG00000205076; HPRD:09002; MIM:600615
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAL7; LGALS7A
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19q13.2

Sequence :: Chromosome: 19; NC_000019.9 (39261608..39264157, complement)

See LGALS7 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

high resolution crystal structure of Gal-7 at 1.4 A (a dimer) and its 1.7 A structure in complex with an inhibitor, a sulfur-containing 2-O-benzylphosphate galactoside, a possible antineoplastic agent
Title: Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.
Data suggest that the binding of Galectin 7 to Bcl-2 may constitute a new target for enhancing the intrinsic apoptosis pathway.
Title: Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells.
Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.
Title: Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.
The intense immunoexpression of galectins-1, -3, and -7 suggests the participation of these proteins in oral carcinogenesis and their use as markers of biological behavior and tumor progression in squamous cell carcinoma of the tongue.
Title: Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue.
Data show that high levels of galectin-7 expression in breast cancer cells drastically increased their ability to metastasize to lungs and bones, and were restricted to high-grade breast carcinomas.
Title: Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells.
Proteomics analysis revealed that galectin-7 was highly expressed in esophageal squamous cell carcinoma and could be used as a potential biomarker.
Title: Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysis.
Data show that Galectine-7 gene was 8 times up-regulated in bronchial epithelial cells from asthmatic children after RSV infection in vitro and overexpressed in bronchial epithelial cells in asthma in vivo.
Title: [Galectin-7 is associated with bronchial epithelial cell apoptosis in asthmatic children].
galectin-7 increases the expression of MMP-9 through the p38 MAPK signaling pathway
Title: Induction of matrix metalloproteinase-9 by galectin-7 through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma cells.
abnormal expression of galectin-7 in lymphoma cells is not dependent on p53, but is rather associated with DNA hypomethylation.
Title: Increased galectin-7 gene expression in lymphoma cells is under the control of DNA methylation.
Associations between MMP-9 and galectins-1 and -7 in situ indicate presence in hypopharyngeal and laryngeal squamous cell carcinomas.
Title: Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7.

Submit: New GeneRIF Correction See all (14)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:110154	BioGRID:119325	INSIG2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110154	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110154	BioGRID:113241	USP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110154	BioGRID:115283	USP15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110154	BioGRID:124165	USP38	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110154	BioGRID:120380	WIPI1	BioGRID	PubMed	Affinity Capture-MS

General gene information

Markers

RH80063 (e-PCR)
- UniSTS:91678

RH66782 (e-PCR)
- UniSTS:55229

Homology

Homologs of the LGALS7 gene: The LGALS7 gene is conserved in , dog, cow, mouse, and rat.

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General protein information

Preferred Names: galectin-7

Names: galectin-7; galectin 7

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002307.3 → NP_002298.1 galectin-7

Status: REVIEWED

Source sequence(s)

BP225960

Consensus CDS

CCDS33012.1

UniProtKB/Swiss-Prot

P47929

Related

ENSP00000367891, ENST00000378626

Conserved Domains (1) summary

cd00070
Location:5 – 133
Blast Score: 368

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

39261608..39264157, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

35727171..35729720

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC022144.8 (31761..34310)	None
genomic	CH471126.1	EAW56817.1
mRNA	BM681659.1	None
mRNA	BP225960.1	None
mRNA	CR456917.1	CAG33198.1
mRNA	CV575179.1	None