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LGALS7 lectin, galactoside-binding, soluble, 7 [ Homo sapiens (human) ]

Gene ID: 3963, updated on 21-Jul-2014
Official Symbol
LGALS7provided by HGNC
Official Full Name
lectin, galactoside-binding, soluble, 7provided by HGNC
Primary source
HGNC:6568
See related
Ensembl:ENSG00000205076; HPRD:09002; MIM:600615; Vega:OTTHUMG00000182606
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL7; LGALS7A
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
See LGALS7 in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (38770968..38773517, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39261608..39264157, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene actinin, alpha 4 Neighboring gene calpain 12 Neighboring gene lectin, galactoside-binding, soluble, 7B Neighboring gene lectin, galactoside-binding, soluble, 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
galectin-7
Names
galectin-7
galectin 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002307.3NP_002298.1  galectin-7

    See proteins identical to NP_002298.1

    Status: REVIEWED

    Source sequence(s)
    BP225960
    Consensus CDS
    CCDS33012.1
    UniProtKB/Swiss-Prot
    P47929
    Related
    ENSP00000367891, OTTHUMP00000269637, ENST00000378626, OTTHUMT00000462636
    Conserved Domains (1) summary
    cd00070
    Location:5133
    Blast Score: 408
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    38770968..38773517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    35727171..35729720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    39262048..39264610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)