Prosbeta2 Proteasome beta2 subunit [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Prosbeta2provided by Flybase
Official Full Name: Proteasome beta2 subunitprovided by Flybase
Primary source: FLYBASE:FBgn0023174
Locus tag: Dmel_CG3329
Gene type: protein coding
RNA name: proteasome beta2 subunit
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3329; anon-EST:fe1E6; anon-EST:fe1G6; beta2; beta2_dm; CG3329; Dmel\CG3329; DTS-7; Dts7; DTS7; l(3)DTS7; Prosbeta; Prosbeta 2

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Genomic context

Location :: 71B1-71B1

Sequence :: Chromosome: 3L; NT_037436.3 (14993036..14994419)

See Prosbeta2 in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:64952	BioGRID:59471	CG11885	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:67195	CG12321	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:62193	CG13319	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:62299	CG13349	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:58648	CG15717	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:61006	CG17331	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:65924	CG2046	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:67901	CG31120	BioGRID	PubMed	Two-hybrid
BioGRID:64952	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:64952	BioGRID:64793	Klc	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:63468	Mov34	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:57823	N	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:64952	BioGRID:61305	Pomp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:66629	Pros25	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:65155	Pros26	BioGRID	PubMed	Affinity Capture-MS; Phenotypic Enhancement
BioGRID:64952	BioGRID:67764	Pros26.4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:58925	Pros28.1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:63019	Pros29	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:60450	Pros35	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:59383	Pros45	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:69878	Prosalpha1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:62645	Prosalpha5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:60764	Prosalpha6T	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:61847	Prosalpha7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:70078	Prosbeta1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:66247	Prosbeta3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:59678	Prosbeta4R2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:69549	Prosbeta5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:65850	Prosbeta7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:58659	REG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:65442	Rpn1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:59913	Rpn11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:68320	Rpn2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:62384	Rpn6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:67596	Rpn7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:67740	Rpn9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:61576	Rpt1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:58462	Rpt3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:58056	Rpt4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:67743	Tbp-1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64952	BioGRID:62035	Tret1-1	BioGRID	PubMed	Two-hybrid

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General gene information

Pathways from BioSystems

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
G1/S DNA Damage Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Proteasome, organism-specific biosystem (from KEGG)
Proteasome, organism-specific biosystemThe proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processin...
Proteasome, conserved biosystem (from KEGG)
Proteasome, conserved biosystemThe proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processin...
Proteasome Degradation, organism-specific biosystem (from WikiPathways)
Proteasome Degradation, organism-specific biosystem
Proteasome Degradation
Proteasome, 20S core particle, organism-specific biosystem (from KEGG)
Proteasome, 20S core particle, organism-specific biosystemStructural complex; Genetic information processing; Proteasome
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Apoptosis, organism-specific biosystem (from REACTOME)
Regulation of Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of activated PAK-2p34 by proteasome mediated degradation, organism-specific biosystem (from REACTOME)
Regulation of activated PAK-2p34 by proteasome mediated degradation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystem (from REACTOME)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystem (from REACTOME)
Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystem (from REACTOME)
Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Independent DNA Damage Response, organism-specific biosystem (from REACTOME)
p53-Independent DNA Damage Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Independent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
p53-Independent G1/S DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
proteolysis involved in cellular protein catabolic process	IEA Inferred from Electronic Annotation more info
response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
proteasome core complex	ISS Inferred from Sequence or Structural Similarity more info

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General protein information

Preferred Names: CG3329 gene product from transcript CG3329-RA

Names: 20s proteasome; CG3329-PA; Prosbeta2-PA; anon-fast-evolving-1E6; anon-fast-evolving-1G6; b2 subunit; beta2 proteosome subunit; proteasome beta2 subunit

NP_524076.2

EC 3.4.25.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

14993036..14994419

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079352.3 → NP_524076.2 proteasome beta2 subunit [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VUJ1

Related

FBpp0075382

Conserved Domains (2) summary

cd03763
Location:42 – 228
Blast Score: 907

proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

pfam12465
Location:231 – 266
Blast Score: 126

Pr_beta_C; Proteasome beta subunits C terminal