LYZ lysozyme (renal amyloidosis) [Gallus gallus] - Gene

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Summary

Symbol: LYZprovided by CGNC
Full Name: lysozyme (renal amyloidosis)provided by CGNC
Primary source: CGNC:7570
See related: Ensembl:ENSGALG00000009963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LYZC

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Genomic context

Location :: chromosome: 1

Sequence :: Chromosome: 1; NC_006088.3 (35383316..35387003)

See LYZ in MapViewer

Chromosome 1 - NC_006088.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The study provides a quantitative description of the solvation properties of lysozyme in water/ethanol mixtures, which has been obtained by a simultaneous analysis of small-angle neutron scattering and differential scanning calorimetry experiments.
Title: Preferential solvation of lysozyme in water/ethanol mixtures.
The study applied a protein mapping method to nine structures of hen egg-white lysozyme, and idenified ligand binding sites.
Title: Robust identification of binding hot spots using continuum electrostatics: application to hen egg-white lysozyme.
Sp1 participates in recruiting Orc2 to the origin of lysozyme GAS41.
Title: In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites.
investigation of protein conformation/stability of lysozyme by comparison with analogs with varying degrees of ester linkages replacing amide/peptide linkages using molecular dynamics simulations
Title: Ester-linked hen egg white lysozyme shows a compact fold in a molecular dynamics simulation - possible causes and sensitivity of experimentally observable quantities to structural changes maintaining this compact fold.
The study presents conformational responses of hen egg white lysozyme in the tetragonal crystal by X-ray diffraction experiments using a humidity-control apparatus, which provided air flow of 20-98%rh at 298 K.
Title: A few low-frequency normal modes predominantly contribute to conformational responses of hen egg white lysozyme in the tetragonal crystal to variations of molecular packing controlled by environmental humidity.
The interaction between gold nanorods and lysozyme has been monitored using spectroscopic techniques.
Title: Interaction of lysozyme with gold nanorods: conformation and activity investigations.
These results demonstrate the enhanced chaperone activity of modified beta-casein and its protective effects on lysozyme refolding.
Title: Acidic residue modifications restore chaperone activity of β-casein interacting with lysozyme.
The orientation of lysozyme adsorbed to a negatively charged ligand surface was predicted by a rigid and a flexible model.
Title: Modelling of lysozyme binding to a cation exchange surface at atomic detail: the role of flexibility.
The whole hydration sites (HS) of lysozyme are composed of 195 single HSs and 38 clustered ones (CHS), and divided into 231 external HSs (EHS) and 2 internal ones (IHS).
Title: Structural characteristics of hydration sites in lysozyme.
The NMR results indicate that low-lying excited state conformers of hen lysozyme are characterized by slowly fluctuating local conformations around these cavities, attributed to the opportunities for water molecules to penetrate into the cavities.
Title: Cavity hydration as a gateway to unfolding: an NMR study of hen lysozyme at high pressure and low temperature.

Submit: New GeneRIF Correction See all (43)

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:676478	BioGRID:113164	UBC		BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
lysozyme activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
cell wall macromolecule catabolic process	IEA Inferred from Electronic Annotation more info
cytolysis	IEA Inferred from Electronic Annotation more info
defense response to bacterium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: lysozyme C

Names: lysozyme C; dystrophin; allergen Gal d IV; egg white lysozyme; 1,4-beta-N-acetylmuramidase C

NP_990612.1

EC 3.2.1.17

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205281.1 → NP_990612.1 lysozyme C precursor

Status: PROVISIONAL

Source sequence(s)

V00428

UniProtKB/Swiss-Prot

P00698

Related

ENSGALP00000016177, ENSGALT00000016196

Conserved Domains (1) summary

cd00119
Location:19 – 143
Blast Score: 462

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: Build 3.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Gallus_gallus-4.0 Primary Assembly

Genomic

NC_006088.3 Reference Gallus_gallus-4.0 Primary Assembly

Range

35383316..35387003

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AF405540.1	AAL01041.1
genomic	AF410481.1	AAL69327.1
genomic	J00885.1	AAA48943.1
genomic	J00886.1	AAD10202.1
mRNA	CR390743.1	None	Leghorn
mRNA	V00428.1	CAA23711.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P00698.1	GenPept	UniProtKB/Swiss-Prot:P00698
Q6LEL2	GenPept	UniProtKB/TrEMBL:Q6LEL2
Q90XC9	GenPept	UniProtKB/TrEMBL:Q90XC9