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    Brd Bearded [ Drosophila melanogaster ]

    Gene ID: 39620, updated on 10-May-2012
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    Summary

    Official Symbol
    Brdprovided by Flybase
    Official Full Name
    Beardedprovided by Flybase
    Primary source
    FLYBASE:FBgn0000216
    Locus tag
    Dmel_CG3096
    Gene type
    protein coding
    RNA name
    bearded
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    brd; Brd-C; CG3096; DmelCG3096; Dmel\CG3096
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    Genomic context

    Location :
    71A4-71A4; 3-42 cM
    Sequence :
    Chromosome: 3L; NT_037436.3 (14965769..14966298)
    See Brd in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene Brother of Bearded A Neighboring gene Twin of m4 Neighboring gene CG3396 gene product from transcript CG3396-RB Neighboring gene ncRNA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex. Duncan EJ, et al. Genome Res, 2010 Jul. PMID 20458100.
    2. Silencing by small RNAs is linked to endosomal trafficking. Lee YS, et al. Nat Cell Biol, 2009 Sep. PMID 19684574.
    3. Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Fontana JR, et al. Dev Biol, 2009 Sep 15. PMID 19580805.
    4. Genome engineering-based analysis of Bearded family genes reveals both functional redundancy and a nonessential function in lateral inhibition in Drosophila. Chanet S, et al. Genetics, 2009 Aug. PMID 19528324.
    5. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626.

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta
      Title: Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta.
    2. inhibition of Neur by Brd proteins is important for precise spatial regulation of Dl signaling
      Title: Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:64945 BioGRID:67310 Dl    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:64945 BioGRID:67421 H    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:64945 BioGRID:57823 N    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:64945 BioGRID:67078 Ubx    BioGRID  PubMed Reconstituted Complex 
    BioGRID:64945 BioGRID:61105 amos    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:64945 BioGRID:66253 neur    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sensory organ precursor cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG3096 gene product from transcript CG3096-RA
    Names
    Brd-PA
    CG3096-PA
    bearded
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      14965769..14966298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057541.4 → NP_476889.1  bearded [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16528
      Related
      FBpp0075374
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AY863981.1 AAW64297.1
    genomic AY863987.1 AAW64303.1
    genomic AY863979.1 AAW64295.1
    genomic AY863996.1 AAW64312.1
    genomic AY863997.1 AAW64313.1
    mRNA BT100176.1 ACY26171.1
    genomic AY863988.1 AAW64304.1
    genomic AY863993.1 AAW64309.1
    genomic AY863986.1 AAW64302.1
    genomic AE014296.4 AAF49693.1
    genomic AY863985.1 AAW64301.1
    genomic AY863994.1 AAW64310.1
    genomic AY863989.1 AAW64305.1
    genomic AY863984.1 AAW64300.1
    genomic AY863990.1 AAW64306.1
    genomic AY863976.1 AAW64292.1
    genomic AY863980.1 AAW64296.1
    genomic AY863982.1 AAW64298.1
    mRNA AF016542.1 AAC47751.1
    genomic AY863991.1 AAW64307.1
    genomic AY863978.1 AAW64294.1
    genomic AY863995.1 AAW64311.1
    genomic AY863977.1 AAW64293.1
    genomic AY863992.1 AAW64308.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16528.1 GenPept
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    Additional Links

    Gene LinkOut

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