ESR1 estrogen receptor 1 [Gallus gallus (chicken)] - Gene

Summary

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Symbol: ESR1provided by CGNC
Full Name: estrogen receptor 1provided by CGNC
Primary source: CGNC:9821
See related: Ensembl:ENSGALG00000012973
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus

Genomic context

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Location :: chromosome: 3

Sequence :: Chromosome: 3; NC_006090.3 (48327678..48431441)

See ESR1 in MapViewer

Chromosome 3 - NC_006090.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

There were no significant differences in ERalpha mRNA expression during stress induced by fasting and refeeding.
Title: Changes in estrogen receptor ERalpha and ERbeta expression in chicken (Gallus domesticus) adrenal gland during short-fasting and refeeding.
cell-specific distribution of ERalpha and AR in the anterior pituitary from adult cockerels by immunohistochemistry
Title: Cell-specific distributions of estrogen receptor alpha (ERα) and androgen receptor (AR) in anterior pituitary glands from adult cockerels as revealed by immunohistochemistry.
Data show that estrogen receptor 1 mRNA is over-expressed in early-stage tumors, suggesting that expression of the oviduct-related genes may be regulated by estrogen.
Title: Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?
ERalpha plays an important role in sex differentiation of the reproductive tract in female chicken embryos and can mediate xenoestrogen-induced disturbances of sex differentiation.
Title: Activation of estrogen receptor alpha disrupts differentiation of the reproductive organs in chicken embryos.
immunohistochemical (IHC) localization of oestrogen receptor alpha was studied in the developing left ovary of 14.5-day-old chick embryos; intracellular localization was cytoplasmic, nuclear, or both
Title: Immunohistochemical localization of oestrogen receptor alpha in the various cell categories of chick embryo ovary.
Down-regulation of DMRT1 and up-regulation of ER alpha in rooster testes treated with exogenous pEGFP-N1-chicken male hypemethylated (cMHM) plasmid might indicate a novel cMHM non-coding RNA-mediated mechanism in avian sex differentiation.
Title: Exogenous cMHM regulates the expression of DMRT1 and ER alpha in avian testes.
Results describe the efects of daidzein, alone or in combination with estrogen, on estrogen receptor alpha and/or beta-mediated transactivation and on chicken hepatic vitellogenin II expression.
Title: Dual effects of daidzein on chicken hepatic vitellogenin II expression and estrogen receptor-mediated transactivation in vitro.
ERalpha is localized in the nucleus of all cell subpopulations of the left ovary and only in epithelial cells of the lacunar channels of the right ovary.
Title: Immunohistochemical detection of estrogen receptor alpha in the growing and regressing ovaries of newly hatched chicks.
The ontogeny of ESR1 and its co-localization with pituitary hormones in the chick pituitary was studied.
Title: Ontogeny of estrogen receptor (ER) alpha and its co-localization with pituitary hormones in the pituitary gland of chick embryos.
Content of estrogen receptor-alpha (ER-alpha) isoforms related to degree of brain development in chicks (Estrogen receptor alpha)
Title: Changes in the content of progesterone receptor isoforms and estrogen receptor alpha in the chick brain during embryonic development.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Nuclear Receptors, organism-specific biosystem (from WikiPathways)
Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...

General gene information

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Homology

Homologs of the ESR1 gene: The ESR1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
estrogen receptor activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
steroid binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: estrogen receptor

Names: estrogen receptor; ER; ER-alpha; estradiol receptor; estrogen receptor alpha; estrogen receptor, alpha; nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205183.2 → NP_990514.1 estrogen receptor

Status: PROVISIONAL

Source sequence(s)

X03805

UniProtKB/Swiss-Prot

P06212

Related

ENSGALP00000021137, ENSGALT00000021168

Conserved Domains (4) summary

cd06949
Location:304 – 541
Blast Score: 992

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:174 – 255
Blast Score: 500

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 – 175
Blast Score: 500

Oest_recep; Oestrogen receptor

pfam12743
Location:546 – 589
Blast Score: 157

ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: Build 3.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Gallus_gallus-4.0 Primary Assembly

Genomic

NC_006090.3 Reference Gallus_gallus-4.0 Primary Assembly

Range

48327678..48431441

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AADN03003029.1	None
genomic	AADN03003347.1 (863534..889590)	None
mRNA	HQ340611.1	ADQ38960.1
mRNA	X03805.1	CAA27431.1
		CAA27432.1
		CAA27433.1