TNNC1 troponin C1, slow skeletal and cardiac type [Gallus gallus (chicken)] - Gene

Summary

Symbol: TNNC1provided by CGNC
Full Name: troponin C1, slow skeletal and cardiac typeprovided by CGNC
Primary source: CGNC:49617
See related: Ensembl:ENSGALG00010028025
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: PCTNC1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (643058..648527, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (769019..774511, complement)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the inhibitory effect of EGCg on myofilament Ca(2+) activation may be related to an enhanced Ca(2+)-Mg(2+)exchange at sites III and IV of cTnC, which might reduce the myosin crossbridge dependent component of thin filament activation.
Title: The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits magnesium binding to the C-domain of cardiac troponin C.
cysteine substitution had no effect on Ca2+ binding on cTnC in solution
Title: Intramolecular interactions in the N-domain of cardiac troponin C are important determinants of calcium sensitivity of force development.
kinetic analysis of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes
Title: Structural kinetics of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes.
in the absence of Ca(2+), the N-domain of TnC moves independently from the rest of the complex
Title: Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of myosin II complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: troponin C, slow skeletal and cardiac muscles

Names: TN-C; cardiac troponin C; troponin C type 1 (slow)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205133.2 → NP_990464.1 troponin C, slow skeletal and cardiac muscles

See identical proteins and their annotated locations for NP_990464.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000250

UniProtKB/Swiss-Prot

P09860

Related

ENSGALP00010041661.1, ENSGALT00010067918.1

Conserved Domains (1) summary

PTZ00184
Location:9 → 157

PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

643058..648527 complement

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GenBank, FASTA, Sequence Viewer (Graphics)