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LGALS4 lectin, galactoside-binding, soluble, 4 [ Homo sapiens (human) ]

Gene ID: 3960, updated on 29-Jul-2014
Official Symbol
LGALS4provided by HGNC
Official Full Name
lectin, galactoside-binding, soluble, 4provided by HGNC
Primary source
HGNC:6565
See related
Ensembl:ENSG00000171747; HPRD:03949; MIM:602518; Vega:OTTHUMG00000182608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL4; L36LBP
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
See LGALS4 in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (38801671..38813100, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39292311..39303740, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene lectin, galactoside-binding, soluble, 7 Neighboring gene lectin, galactoside-binding, soluble, 7B Neighboring gene enoyl CoA hydratase 1, peroxisomal Neighboring gene heterogeneous nuclear ribonucleoprotein L

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
galectin-4
Names
galectin-4
gal-4
galectin 4
antigen NY-CO-27
lactose-binding lectin 4
L-36 lactose-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006149.3NP_006140.1  galectin-4

    See proteins identical to NP_006140.1

    Status: REVIEWED

    Source sequence(s)
    AA130458, AA583424, AK290269
    Consensus CDS
    CCDS12521.1
    UniProtKB/Swiss-Prot
    P56470
    UniProtKB/TrEMBL
    Q6FHZ4
    Related
    ENSP00000302100, OTTHUMP00000269641, ENST00000307751, OTTHUMT00000462641
    Conserved Domains (1) summary
    cd00070
    Location:18147
    Blast Score: 429
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    38801671..38813100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    35739052..35750477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    39292792..39304214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)