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TFAP2A transcription factor AP-2 alpha [ Gallus gallus (chicken) ]

Gene ID: 395982, updated on 3-Apr-2024

Summary

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Symbol
TFAP2Aprovided by CGNC
Full Name
transcription factor AP-2 alphaprovided by CGNC
Primary source
CGNC:9685
See related
Ensembl:ENSGALG00010009668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TFAP2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (63017677..63033999)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (62966466..62982767)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene male germ cell associated kinase Neighboring gene transmembrane protein 14C-like Neighboring gene glucosaminyl (N-acetyl) transferase 2 Neighboring gene uncharacterized LOC101749691 Neighboring gene uncharacterized LOC121109794 Neighboring gene heat shock transcription factor X1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds. Shen H, et al. Dev Biol, 1997 Aug 15. PMID 9268573
  2. AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity. Mitchell DL, et al. Exp Cell Res, 2010 Jan 15. PMID 19699737
  3. AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord. Xu X, et al. Neuroscience, 2017 Jan 6. PMID 27984181

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chicken TFAP2 expression was mapped from neural crest cell migration until E5.5. Transcripts were high in the migratory cranial neural crest cells, in facial and limb bud mesenchyme. Negative regulation of TFAP2 by all-trans-retinoic acid and positive regulation by FGF4 was shown in this study.
    Title: Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds.
  2. Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta have distinct functions in dorsal interneuron specification and differentiation.
    Title: AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.
  3. Results indicate that AP-2 alpha is a transcriptional repressor of FGFR1 gene expression during skeletal myogenesis.
    Title: AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcription factor AP-2-alpha
Names
AP-2 transcription factor
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
transcription factor AP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205094.2 → NP_990425.2  transcription factor AP-2-alpha

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YBP0, O13111
    Related
    ENSGALP00010013358.1, ENSGALT00010023083.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    63017677..63033999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015275845.4 → XP_015131331.1  transcription factor AP-2-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y715, O13111
    Related
    ENSGALP00010013360.1, ENSGALT00010023085.1
    Conserved Domains (1) summary
    pfam03299
    Location:205 → 405
    TF_AP-2; Transcription factor AP-2

  2. XM_046918962.1 → XP_046774918.1  transcription factor AP-2-alpha isoform X4

  3. XM_015275844.4 → XP_015131330.1  transcription factor AP-2-alpha isoform X5

    UniProtKB/TrEMBL
    A0A8V0Y4R4
    Related
    ENSGALP00010013354.1, ENSGALT00010023078.1
    Conserved Domains (1) summary
    pfam03299
    Location:273 → 473
    TF_AP-2; Transcription factor AP-2

  4. XM_046918955.1 → XP_046774911.1  transcription factor AP-2-alpha isoform X6

  5. XM_046918956.1 → XP_046774912.1  transcription factor AP-2-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V0XYI6

  6. XM_015275847.4 → XP_015131333.1  transcription factor AP-2-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V0XYI6, O13111
    Related
    ENSGALP00010013352.1, ENSGALT00010023074.1
    Conserved Domains (1) summary
    pfam03299
    Location:203 → 403
    TF_AP-2; Transcription factor AP-2

  7. XM_015275848.3 → XP_015131334.1  transcription factor AP-2-alpha isoform X3

    UniProtKB/TrEMBL
    O13111
    Conserved Domains (1) summary
    pfam03299
    Location:203 → 403
    TF_AP-2; Transcription factor AP-2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    62966466..62982767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910409.1 → XP_046766365.1  transcription factor AP-2-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y715

  2. XM_046910413.1 → XP_046766369.1  transcription factor AP-2-alpha isoform X4

  3. XM_046910408.1 → XP_046766364.1  transcription factor AP-2-alpha isoform X8

  4. XM_046910407.1 → XP_046766363.1  transcription factor AP-2-alpha isoform X7

  5. XM_046910410.1 → XP_046766366.1  transcription factor AP-2-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V0XYI6

  6. XM_046910411.1 → XP_046766367.1  transcription factor AP-2-alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V0XYI6

  7. XM_046910412.1 → XP_046766368.1  transcription factor AP-2-alpha isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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