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CG4613 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39586, updated on 4-Apr-2024

Summary

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Official Symbol
CG4613provided by FlyBase
Primary source
FLYBASE:FBgn0036427
Locus tag
Dmel_CG4613
See related
AllianceGenome:FB:FBgn0036427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4613; SP40
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to human HPN (hepsin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
70E1-70E1; 3-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14519760..14521690, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14512860..14514790, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46031 Neighboring gene big bang Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial phosphate carrier protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defensive repertoire of Drosophila larvae in response to toxic fungi. Trienens M, et al. Mol Ecol, 2017 Oct. PMID 28746736
  2. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
  3. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
  4. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article
  5. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4613-PB
CG4613-PC
NP_001261841.1
NP_648707.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14519760..14521690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274912.1 → NP_001261841.1  uncharacterized protein Dmel_CG4613, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUF0
    Conserved Domains (2) summary
    smart00020
    Location:136 → 362
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:137 → 362
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_140450.2 → NP_648707.2  uncharacterized protein Dmel_CG4613, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648707.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUF0
    Conserved Domains (2) summary
    smart00020
    Location:136 → 362
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:137 → 362
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUF0 Q9VUF0

Gene LinkOut

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