LGALS3 lectin, galactoside-binding, soluble, 3 [Homo sapiens] - Gene

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Summary

Official Symbol: LGALS3provided by HGNC
Official Full Name: lectin, galactoside-binding, soluble, 3provided by HGNC
Primary source: HGNC:6563
See related: Ensembl:ENSG00000131981; HPRD:01090; HPRD:17026; MIM:153619; Vega:OTTHUMG00000171030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
Summary: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Annotation information: Note: GeneID 3958 had the official symbol LGALS2 and was identified as the human homolog of mouse Mac-2 (macrophage galactose-specific lectin) in M35368.1 and PMID: 2402511. The official symbol for this gene is now LGALS3. [30 Mar 2010]

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Genomic context

Location :: 14q22.3

Sequence :: Chromosome: 14; NC_000014.8 (55595935..55612148)

See LGALS3 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Have identified galectin-1 and galectin-3 as novel partners for VWF, and these proteins may modulate VWF-mediated thrombus formation.
Title: Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor.
Data demonstrated that in addition to galectin-3, HK III and cyclin A profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.
Title: Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.
DC-expressed Gal-1 and Gal-3 are regulatory molecules that favor the inhibition of T cell activation.
Title: Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-γ production.
galectin-3 protein is resistant to prostate-specific antigen (PSA) cleavage
Title: Tyrosine-phosphorylated galectin-3 protein is resistant to prostate-specific antigen (PSA) cleavage.
Galectin-3 is overexpressed in hepatocellular carcinoma tissues and is correlated with the tumor differentiation.
Title: [Serum and tissue expressions of galectin-3 in hepatocellular carcinoma and the clinical significances].
Methodology and technical requirements of the galectin-3 test for the preoperative characterization of thyroid nodules.
Title: Methodology and technical requirements of the galectin-3 test for the preoperative characterization of thyroid nodules.
changes in the cellular level of galectin-3 correlate with the development of clear cell renal cell carcinoma.
Title: Changes in the expression and subcellular distribution of galectin-3 in clear cell renal cell carcinoma.
We didn't reveal any important correlations between clinicopathological findings and galectin-3 and cyclin D1 expression and in non small cell lung cancer. We didn't observed also prognostic value of cyclin D1 or galectin-3 expression.
Title: Galectin-3 and cyclin D1 expression in non-small cell lung cancer.
The high- to ultra-high-resolution crystal structures of the carbohydrate recognition domain of galectin-3 are reported in the ligand-free state and in complex with lactose or glycerol.
Title: The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics.
Gal3 is expressed constitutively in neonatal cord blood, correlating positively with gestational age & may play a role in innage immunity. It is higher in small-for-gestational-age infants. Stimulation with invasive S. agalactiae induced Gal3.
Title: Galectin-3 in cord blood of term and preterm infants.

Submit: New GeneRIF Correction See all (211)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	CBP35 was identified as part of a complex of ribonucleoproteins that bind to RRE RNA, an interaction that is abolished by Rev	PubMed
Tat	tat	HIV-1 Tat upregulates galectin-3 (carbohydrate-binding protein 35; CBP35) expression in an Sp-1 dependent manner	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P17931	P48729	CSNK1A1	HPRD	PubMed
P17931	P68400	CSNK2A1	HPRD	PubMed
P17931	P19784	CSNK2A2	HPRD	PubMed
P17931	O60494	CUBN	HPRD	PubMed
P17931	Cysteine and histidine rich 1	CYHR1	HPRD	PubMed
P17931	P15502	ELN	HPRD	PubMed
P17931	P12318	FCGR2A	HPRD	PubMed
P17931	P57678	GEMIN4	HPRD	PubMed
P17931	Q08380	LGALS3BP	HPRD	PubMed
P17931	P55344	LIM2	HPRD	PubMed
P17931	P08253	MMP2	HPRD	PubMed
P17931	Q99972	MYOC	HPRD	PubMed
P17931	Q9UMX1	SUFU	HPRD	PubMed
BioGRID:110149	BioGRID:118844	C1GALT1C1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110149	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110149	BioGRID:108321	ELN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110149	BioGRID:108506	FCGR2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:110149	BioGRID:119102	GEMIN4	BioGRID	PubMed	Reconstituted Complex
BioGRID:110149	BioGRID:110147	LGALS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110149	BioGRID:110150	LGALS3BP	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Reconstituted Complex

Function	Evidence Code	Pubs
IgE binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sugar binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
RNA splicing	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
extracellular matrix organization	IEA Inferred from Electronic Annotation more info
innate immune response	TAS Traceable Author Statement more info
mRNA processing	IEA Inferred from Electronic Annotation more info
skeletal system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
extracellular region	IEA Inferred from Electronic Annotation more info
mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info	PubMed
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info
spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: galectin-3

Names: galectin-3; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017089.1 RefSeqGene

Range

5001..21214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001177388.1 → NP_001170859.1 galectin-3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL139316, BG332134, BU681070

Conserved Domains (1) summary

cd00070
Location:117 – 179
Blast Score: 154

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
NM_002306.3 → NP_002297.2 galectin-3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AB006780, BU681070, CD518618

Consensus CDS

CCDS41956.1

UniProtKB/Swiss-Prot

P17931

Related

ENSP00000254301, OTTHUMP00000244927, ENST00000254301, OTTHUMT00000411309

Conserved Domains (1) summary

cd00070
Location:117 – 244
Blast Score: 359

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RNA

NR_003225.2 RNA Sequence

Description

Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL139316, BU681070, BX641090

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

55595935..55612148

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

35758537..35774750

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB086821.1	BAC45249.1
genomic	AF031425.1	AAB86584.1
genomic	AL139316.5 (80956..97148)	None
genomic	CH471061.1	EAW80658.1
		EAW80660.1
genomic	HI179168.1	CBX53892.1
genomic	U10300.1	None
mRNA	AB006780.1	BAA22164.1
mRNA	AB209391.1	BAD92628.1
mRNA	AF266280.1	AAG44701.1
		AAG44702.1
mRNA	AK314929.1	BAG37435.1
mRNA	BC001120.2	AAH01120.1
mRNA	BC053667.1	AAH53667.1
mRNA	BC068068.1	AAH68068.1
mRNA	BC128253.1	None
mRNA	BC128403.1	None
mRNA	BG332134.1	None
mRNA	BQ645629.1	None
mRNA	BU681070.1	None
mRNA	BX161455.1	CAD61918.1
mRNA	BX641090.1	CAE46042.1
mRNA	CD518618.1	None
mRNA	CR456897.1	CAG33178.1
mRNA	CR542097.1	CAG46894.1
mRNA	M35368.1	AAA88086.1
mRNA	M36682.1	AAA36163.1
mRNA	M57710.1	AAA35607.1
mRNA	M64303.1	None
mRNA	S59012.1	AAB26229.1
other-genetic	DQ892594.2	ABM83520.1
other-genetic	EU176706.1	ABW03507.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P17931.5	GenPept	UniProtKB/Swiss-Prot:P17931
Q6FGL0	GenPept	UniProtKB/TrEMBL:Q6FGL0
Q6MZI9	GenPept	UniProtKB/TrEMBL:Q6MZI9
Q6NVH9	GenPept	UniProtKB/TrEMBL:Q6NVH9
Q86TY5	GenPept	UniProtKB/TrEMBL:Q86TY5
Q8IXB9	GenPept	UniProtKB/TrEMBL:Q8IXB9
Q9H2J5	GenPept	UniProtKB/TrEMBL:Q9H2J5
Q9H2J6	GenPept	UniProtKB/TrEMBL:Q9H2J6