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    ACAN aggrecan [ Gallus gallus ]

    Gene ID: 395798, updated on 4-May-2012
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    Summary

    Symbol
    ACANprovided by CGNC
    Full Name
    aggrecanprovided by CGNC
    Primary source
    CGNC:5079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    AGC1
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    Genomic context

    Location :
    chromosome: 10
    Sequence :
    Chromosome: 10; NC_006097.3 (12540336..12565461, complement)
    See ACAN in MapViewer

    Chromosome 10 - NC_006097.3Genomic Context describing neighboring genes Neighboring gene milk fat globule-EGF factor 8 protein Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene microRNA mir-1720 Neighboring gene apoptosis enhancing nuclease

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH. Heng BC, et al. J Biol Chem, 2008 Nov 21. PMID 18806261.
    2. Mutation analysis of the aggrecan gene in chickens with tibial dyschondroplasia. Ray SA, et al. Poult Sci, 2006 Jul. PMID 16830856.
    3. APBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region. Pirok EW 3rd, et al. J Biol Chem, 2005 Oct 21. PMID 16100116.
    4. Differential versican isoforms and aggrecan expression in the chicken embryo aorta. Arciniegas E, et al. Anat Rec A Discov Mol Cell Evol Biol, 2004 Jul. PMID 15224401.
    5. S103L reactive chondroitin sulfate proteoglycan (aggrecan) mRNA expressed in developing chick brain and cartilage is encoded by a single gene. Li H, et al. Brain Res Mol Brain Res, 1996 Mar. PMID 8965652.

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TSG-6 and aggrecan interact with HA through structurally homologous domains, a process that is differentially regulated by pH
      Title: Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH.
    2. A scan for SNPs in the AGC1 gene of chicken lines divergently selected for tibial dyschondroplasia is reported.
      Title: Mutation analysis of the aggrecan gene in chickens with tibial dyschondroplasia.
    3. APBP-1 has the capacity to repress aggrecan expression and may be an important regulator of aggrecan gene expression
      Title: APBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region.
    4. Immunolocalization patterns observed for versican may be related to the predominance of the V2 isoform during intimal thickening formation and endothelial-mesenchymal transformation.
      Title: Differential versican isoforms and aggrecan expression in the chicken embryo aorta.
    Submit: New GeneRIF Correction
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    General gene information

    Markers

    Genotypes

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    aggrecan core protein
    Names
    aggrecan core protein
    CSPCP
    aggrecan 1
    cartilage-specific proteoglycan core protein
    chondroitin sulfate proteoglycan core protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204955.2 → NP_990286.2  aggrecan core protein precursor

      Status: VALIDATED

      Source sequence(s)
      AADN03005991, U78555
      UniProtKB/TrEMBL
      F1NZX1
      UniProtKB/TrEMBL
      P79787
      Conserved Domains (8) summary
      cd00054
      Location:1835 – 1871
      Blast Score: 138
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:149 – 243
      Blast Score: 458
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:621 – 716
      Blast Score: 469
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05900
      Location:43 – 150
      Blast Score: 495
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:2004 – 2060
      Blast Score: 153
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:1877 – 2000
      Blast Score: 760
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      TIGR03835
      Location:1369 – 1688
      Blast Score: 124
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam07686
      Location:37 – 146
      Blast Score: 112
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: Build 3.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Gallus_gallus-4.0 Primary Assembly

    Genomic

    1. NC_006097.3

      Range
      12540336..12565461, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001232949.2 → XP_001232950.2  

      Conserved Domains (8) summary
      cd00054
      Location:1835 – 1871
      Blast Score: 138
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:149 – 243
      Blast Score: 458
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:621 – 716
      Blast Score: 469
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05900
      Location:43 – 150
      Blast Score: 495
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:2004 – 2060
      Blast Score: 153
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:1877 – 2000
      Blast Score: 760
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      TIGR03835
      Location:1369 – 1688
      Blast Score: 124
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      pfam07686
      Location:37 – 146
      Blast Score: 112
      V-set; Immunoglobulin V-set domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA L21913.1 AAB19128.1
    mRNA M13993.1 AAA48720.1
    mRNA M38187.1 AAA48731.1
    mRNA M88101.1 None
    mRNA U78555.1 AAC60053.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07898.2 GenPept UniProtKB/Swiss-Prot:P07898
    P79787 GenPept UniProtKB/TrEMBL:P79787
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    Additional Links

    Gene LinkOut

      Supplemental Content