RpS4 Ribosomal protein S4 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: RpS4provided by Flybase
Official Full Name: Ribosomal protein S4provided by Flybase
Primary source: FLYBASE:FBgn0011284
Locus tag: Dmel_CG11276
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey270; CG11276; Dmel\CG11276; M(3)69E; rpS4; RPS4; SX4

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Genomic context

Location :: 69F6-69F6

Sequence :: Chromosome: 3L; NT_037436.3 (13034856..13037012)

See RpS4 in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:64829	BioGRID:66929	CG6196	BioGRID	PubMed	Two-hybrid
BioGRID:64829	BioGRID:66553	CG6950	BioGRID	PubMed	Two-hybrid
BioGRID:64829	BioGRID:67212	CG7146	BioGRID	PubMed	Two-hybrid
BioGRID:64829	BioGRID:78234	Parp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:64829	BioGRID:64841	SNCF	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the RpS4 gene: The RpS4 gene is conserved in human, chimpanzee, , cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.

Pathways from BioSystems

Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
Cytoplasmic Ribosomal Proteins, organism-specific biosystem
Cytoplasmic Ribosomal Proteins
Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Termination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide chain elongation, organism-specific biosystem (from REACTOME)
Peptide chain elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
Ribosomal scanning and start codon recognition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosome, organism-specific biosystem (from KEGG)
Ribosome, organism-specific biosystem
Ribosome
Ribosome, conserved biosystem (from KEGG)
Ribosome, conserved biosystem
Ribosome
Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
RNA binding	IEA Inferred from Electronic Annotation more info
structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info
structural constituent of ribosome	NAS Non-traceable Author Statement more info

Process	Evidence Code	Pubs
centrosome duplication	IMP Inferred from Mutant Phenotype more info
centrosome organization	IMP Inferred from Mutant Phenotype more info
mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
translation	ISS Inferred from Sequence or Structural Similarity more info
translation	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
cytosolic small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info
lipid particle	IDA Inferred from Direct Assay more info	PubMed
ribosome	IDA Inferred from Direct Assay more info	PubMed
ribosome	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG11276 gene product from transcript CG11276-RA

Names: CG11276-PA; CG11276-PB; RpS4-PA; RpS4-PB; ribosomal protein S4

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

13034856..13037012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168537.1 → NP_729871.1 ribosomal protein S4, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P41042

Related

FBpp0075618, FBtr0075884

Conserved Domains (4) summary

cd00165
Location:51 – 112
Blast Score: 92

S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...

PLN00036
Location:1 – 258
Blast Score: 1124

PLN00036; 40S ribosomal protein S4; Provisional

pfam00900
Location:94 – 170
Blast Score: 319

Ribosomal_S4e; Ribosomal family S4e

pfam08071
Location:3 – 40
Blast Score: 182

RS4NT; RS4NT (NUC023) domain
NM_079329.2 → NP_524053.2 ribosomal protein S4, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P41042

Related

FBpp0075619, FBtr0075885

Conserved Domains (4) summary

cd00165
Location:51 – 112
Blast Score: 92

S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...

PLN00036
Location:1 – 258
Blast Score: 1124

PLN00036; 40S ribosomal protein S4; Provisional

pfam00900
Location:94 – 170
Blast Score: 319

Ribosomal_S4e; Ribosomal family S4e

pfam08071
Location:3 – 40
Blast Score: 182

RS4NT; RS4NT (NUC023) domain