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LDHC lactate dehydrogenase C [ Homo sapiens (human) ]

Gene ID: 3948, updated on 6-Jul-2014
Official Symbol
LDHCprovided by HGNC
Official Full Name
lactate dehydrogenase Cprovided by HGNC
Primary source
HGNC:6544
See related
Ensembl:ENSG00000166796; HPRD:01027; MIM:150150; Vega:OTTHUMG00000167722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT32; LDH3; LDHX
Summary
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
See LDHC in Epigenomics, MapViewer
Location:
11p15.1
Exon count :
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (18412304..18451246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18433851..18472798)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 3159 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase A-like 6A Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/41 (SFVenvBX08)-expressing microglia exhibit a 170% increase in lactate dehydrogenase (LDH) release PubMed
Envelope transmembrane glycoprotein gp41 env A lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induces a significant lactate dehydrogenase (LDH, a marker of cell death) release from human neuronal and glial cell lines PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
lactate biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
lactate oxidation IEA
Inferred from Electronic Annotation
more info
 
sperm motility IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
L-lactate dehydrogenase C chain
Names
L-lactate dehydrogenase C chain
LDH-C
LDH-X
LDH testis subunit
cancer/testis antigen 32
lactate dehydrogenase C4
lactate dehydrogenase c variant 1
lactate dehydrogenase c variant 3
lactate dehydrogenase c variant 4
NP_002292.1
NP_059144.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011816.1 

    Range
    5001..43941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002301.4NP_002292.1  L-lactate dehydrogenase C chain

    See proteins identical to NP_002292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084117, BC064388
    Consensus CDS
    CCDS7840.1
    UniProtKB/Swiss-Prot
    P07864
    Related
    ENSP00000280704, OTTHUMP00000236651, ENST00000280704, OTTHUMT00000395894
    Conserved Domains (2) summary
    cd05293
    Location:18329
    Blast Score: 1425
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25325
    Blast Score: 1109
    L-LDH-NAD; L-lactate dehydrogenase
  2. NM_017448.3NP_059144.1  L-lactate dehydrogenase C chain

    See proteins identical to NP_059144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084117, BC090043
    Consensus CDS
    CCDS7840.1
    UniProtKB/Swiss-Prot
    P07864
    Conserved Domains (2) summary
    cd05293
    Location:18329
    Blast Score: 1425
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:25325
    Blast Score: 1109
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    18412304..18451246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252918.2XP_005252975.1  

    See proteins identical to XP_005252975.1

    Conserved Domains (1) summary
    cl17195
    Location:1213
    Blast Score: 1001
    LDH_MDH_like; NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family
  2. XM_005252919.2XP_005252976.1  

    See proteins identical to XP_005252976.1

    Conserved Domains (1) summary
    cl17195
    Location:1213
    Blast Score: 1001
    LDH_MDH_like; NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    18119079..18158522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    18433317..18472228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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