My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    Klc Kinesin light chain [ Drosophila melanogaster ]

    Gene ID: 39445, updated on 10-May-2012
    Help top of page

    Summary

    Official Symbol
    Klcprovided by Flybase
    Official Full Name
    Kinesin light chainprovided by Flybase
    Primary source
    FLYBASE:FBgn0010235
    Locus tag
    Dmel_CG5433
    Gene type
    protein coding
    RNA name
    kinesin light chain
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5433; DKLC; Dmel\CG5433; kinesin; klc; KLC
    Help top of page

    Genomic context

    Location :
    69E1-69E1
    Sequence :
    Chromosome: 3L; NT_037436.3 (12739716..12743156, complement)
    See Klc in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 69D Neighboring gene CG32112 gene product from transcript CG32112-RD Neighboring gene CG32109 gene product from transcript CG32109-RA Neighboring gene CG10984 gene product from transcript CG10984-RC Neighboring gene CG10973 gene product from transcript CG10973-RA Neighboring gene CG32113 gene product from transcript CG32113-RB Neighboring gene Huntingtin interacting protein 1

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Falzone TL, et al. Hum Mol Genet, 2010 Nov 15. PMID 20817925.
    3. Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Loiseau P, et al. Development, 2010 Aug. PMID 20630947.
    4. Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape. Jolly AL, et al. Proc Natl Acad Sci U S A, 2010 Jul 6. PMID 20566873.
    5. Negative regulation of active zone assembly by a newly identified SR protein kinase. Johnson EL 3rd, et al. PLoS Biol, 2009 Sep. PMID 19771148.

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. ensconsin promotes productive recruitment of Kinesin-1 to microtubules
      Title: Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
    2. A functional consequence of myosin V's diffusion on microtubules is a significant enhancement of the processive run length of kinesin when both motors are present on the same cargo.
      Title: Myosin V and Kinesin act as tethers to enhance each others' processivity.
    3. Data show that kinesin heavy chain can function independently of the light chain in the oocyte, indicating that it associates with its cargoes by a novel mechanism.
      Title: Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte.
    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_524049.1 NP_728573.1 Aplip1    BIND  PubMed Aplip1 interacts with DKLC. 
    BioGRID:64793 BioGRID:72744 Aplip1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:64793 BioGRID:57571 Appl    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:64793 BioGRID:62383 AttB    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:62245 AttC    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65925 CG10979    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:72495 CG11052    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65816 CG1126    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:57626 CG14627    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:58384 CG15309    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:60710 CG17024    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:61006 CG17331    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:72813 CG18745    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:63269 CG3085    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:59963 CG31646    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:77449 CG32086    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:624980 CG34357    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:66866 CG3610    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:58931 CG3679    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:59823 CG3714    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:59184 CG7101    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:62150 CG8569    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:59909 CG9121    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:58996 CG9609    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:62884 CG9975    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65565 CSN3    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:58597 Cpr11A    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:68822 Dmn    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:64793 BioGRID:62529 Khc    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:64793 BioGRID:64793 Klc    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65742 Mes2    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:77548 Myo95E    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:64459 PGRP-LA    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:63381 PHDP    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:70027 Pk17E    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:66629 Pros25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:65155 Pros26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:58925 Pros28.1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:60450 Pros35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:62645 Prosalpha5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:70078 Prosbeta1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:64952 Prosbeta2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:66247 Prosbeta3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:69549 Prosbeta5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:65850 Prosbeta7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:78288 Rab21    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65211 Rbp6    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:64739 RhoGAP68F    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:64261 akirin    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:66671 d-cup    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:59500 ds    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:57548 ewg    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:61396 gus    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:67071 nonA-l    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:64907 nuf    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:66299 rump    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65300 skl    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:65797 slx1    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:68706 syd    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:66252 tgo    BioGRID  PubMed Two-hybrid 
    BioGRID:64793 BioGRID:59924 tkv    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64793 BioGRID:63051 tud    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule-based movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    microtubule-based process NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    kinesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    kinesin complex NAS
    Non-traceable Author Statement
    more info
    		  
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    CG5433 gene product from transcript CG5433-RA
    Names
    CG5433-PA
    Klc-PA
    kinesin
    kinesin 1 light chain
    kinesin I
    kinesin light chain
    kinesin light chain subunit of kinesin-1
    kinesin-1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      12739716..12743156, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079325.3 → NP_524049.1  kinesin light chain [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46824
      Related
      FBpp0075683, FBtr0075951
      Conserved Domains (3) summary
      cd00189
      Location:280 – 381
      Blast Score: 93
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam09311
      Location:55 – 227
      Blast Score: 502
      Rab5-bind; Rabaptin-like protein
      pfam13424
      Location:224 – 302
      Blast Score: 146
      TPR_12; Tetratricopeptide repeat
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA L11013.1 AAA02481.1
    mRNA AY061164.1 AAL28712.1
    mRNA L11328.1 AAA28669.1
    genomic AE014296.4 AAF49890.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46824.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

      Supplemental Content

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...