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phc2b polyhomeotic homolog 2b (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 394177, updated on 27-Mar-2024

Summary

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Official Symbol
phc2bprovided by ZNC
Official Full Name
polyhomeotic homolog 2b (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1113
See related
Ensembl:ENSDARG00000013224 AllianceGenome:ZFIN:ZDB-GENE-040426-1113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PHC2; zgc:56685
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (48137477..48199277)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (48138747..48200517)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene solute carrier family 2 member 1b Neighboring gene CTTNBP2 N-terminal like a Neighboring gene wingless-type MMTV integration site family, member 2Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Oocyte-specific H2A variant H2af1o is required for cell synchrony before midblastula transition in early zebrafish embryos. Yue HM, et al. Biol Reprod, 2013 Oct. PMID 23946537
  2. Comparative analysis of the testis and ovary transcriptomes in zebrafish by combining experimental and computational tools. Li Y, et al. Comp Funct Genomics, 2004. PMID 18629171, Free PMC Article
  3. The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Le Faou P, et al. Gene, 2011 Apr 1. PMID 21195142
  4. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Yang S, et al. Int J Mol Sci, 2022 Jul 7. PMID 35886872, Free PMC Article
  5. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56685

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polyhomeotic-like 2; polyhomeotic-like protein 2b
Names
gene name (z): polyhomeotic homolog 2b
polyhomeotic-like 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201202.3 → NP_957496.3  polyhomeotic-like protein 2b

    Status: VALIDATED

    Source sequence(s)
    BC139540
    UniProtKB/TrEMBL
    A0A8M1PJ15, F6P2R0
    Related
    ENSDARP00000018055.9, ENSDART00000019706.10
    Conserved Domains (4) summary
    cd09577
    Location:822 → 889
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    smart00454
    Location:823 → 890
    SAM; Sterile alpha motif
    pfam03153
    Location:389 → 554
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam16616
    Location:708 → 820
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    48137477..48199277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172100.4 → XP_005172157.1  polyhomeotic-like 2 isoform X2

    See identical proteins and their annotated locations for XP_005172157.1

    UniProtKB/TrEMBL
    A4QNV8
    Conserved Domains (3) summary
    cd09577
    Location:785 → 852
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    smart00454
    Location:786 → 853
    SAM; Sterile alpha motif
    pfam16616
    Location:671 → 783
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  2. XM_009302666.3 → XP_009300941.1  polyhomeotic-like 2 isoform X2

    See identical proteins and their annotated locations for XP_009300941.1

    UniProtKB/TrEMBL
    A4QNV8
    Conserved Domains (3) summary
    cd09577
    Location:785 → 852
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    smart00454
    Location:786 → 853
    SAM; Sterile alpha motif
    pfam16616
    Location:671 → 783
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  3. XM_021476817.1 → XP_021332492.1  polyhomeotic-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PLZ0

  4. XM_021476816.1 → XP_021332491.1  polyhomeotic-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QA87
    Conserved Domains (2) summary
    cd09577
    Location:802 → 869
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    pfam16616
    Location:688 → 800
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
Nucleotide Protein Strain
Heading Accession and Version

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