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hpda 4-hydroxyphenylpyruvate dioxygenase a [ Danio rerio (zebrafish) ]

Gene ID: 394142, updated on 27-Mar-2024

Summary

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Official Symbol
hpdaprovided by ZNC
Official Full Name
4-hydroxyphenylpyruvate dioxygenase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-986
See related
Ensembl:ENSDARG00000018351 AllianceGenome:ZFIN:ZDB-GENE-040426-986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hpd; fb58f02; zgc:56326; wu:fb58f02
Summary
Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid family metabolic process. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (2814989..2852285)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (2544800..2582079)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 4 Neighboring gene uncharacterized LOC101884896 Neighboring gene DDRGK domain-containing protein 1 Neighboring gene ring finger protein 43 Neighboring gene heat shock transcription factor family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of hepatic tissue in adult female zebrafish (Danio rerio) exposed to atrazine. Jin Y, et al. Arch Environ Contam Toxicol, 2012 Jan. PMID 21594674
  2. An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Labonne JD, et al. Hum Genet, 2016 Jul. PMID 27106595
  3. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
  4. Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. Lee Y, et al. FASEB J, 2020 Jan. PMID 31914627
  5. Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Heid J, et al. Sci Rep, 2017 Dec 4. PMID 29203887, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56326

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4-hydroxyphenylpyruvate dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables lactoylglutathione lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-hydroxyphenylpyruvate dioxygenase
Names
4-hydroxyphenylpyruvic acid oxidase
4HPPD
HPPDase
NP_957461.1
XP_005171786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201167.1 → NP_957461.1  4-hydroxyphenylpyruvate dioxygenase

    See identical proteins and their annotated locations for NP_957461.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046075
    UniProtKB/Swiss-Prot
    Q6TGZ5
    UniProtKB/TrEMBL
    Q7ZUY6
    Conserved Domains (3) summary
    cd07250
    Location:179 → 374
    HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
    cd08342
    Location:19 → 163
    HPPD_N_like; N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
    TIGR01263
    Location:19 → 382
    4HPPD; 4-hydroxyphenylpyruvate dioxygenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    2814989..2852285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171729.3 → XP_005171786.1  4-hydroxyphenylpyruvate dioxygenase isoform X1

    UniProtKB/Swiss-Prot
    Q6TGZ5
    UniProtKB/TrEMBL
    A0A8M2BJ24, F1Q6E1
    Related
    ENSDARP00000016115.7, ENSDART00000020472.8
    Conserved Domains (3) summary
    cd07250
    Location:179 → 374
    HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
    cd08342
    Location:19 → 163
    HPPD_N_like; N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS)
    TIGR01263
    Location:19 → 382
    4HPPD; 4-hydroxyphenylpyruvate dioxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TGZ5.1 GenPept UniProtKB/Swiss-Prot:Q6TGZ5

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