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    ARHGAP5 Rho GTPase activating protein 5 [ Homo sapiens ]

    Gene ID: 394, updated on 11-May-2012
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    Summary

    Official Symbol
    ARHGAP5provided by HGNC
    Official Full Name
    Rho GTPase activating protein 5provided by HGNC
    Primary source
    HGNC:675
    See related
    Ensembl:ENSG00000100852; HPRD:04060; MIM:602680; Vega:OTTHUMG00000170589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GFI2; p190-B; RhoGAP5; p190BRhoGAP
    Summary
    Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    14q12
    Sequence :
    Chromosome: 14; NC_000014.8 (32546495..32628934)
    See ARHGAP5 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506110 Neighboring gene ARHGAP5 antisense RNA 1 (non-protein coding) Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene KIAA1143 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. Tripathi BK, et al. Mol Cell Biol, 2009 Dec. PMID 19822667.
    3. A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. Gen Y, et al. Cancer Lett, 2009 Mar 8. PMID 18996642.
    4. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. Zhan X, et al. Anal Biochem, 2006 Jul 15. PMID 16777052.
    5. P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Vargo-Gogola T, et al. Mol Endocrinol, 2006 Jun. PMID 16469769.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results link Cdk5 to Rho-ROCK signaling via Src and p190RhoGAP and implicate Cdk5 in the regulation of cell contraction, attachment, and migration.
      Title: Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP.
    2. ARHGAP5 (the gene encoding p190-B RhoGAP) is a probable target for the amplification at 14q12, and p190-B RhoGAP promotes cells spreading and migration by negatively regulating RhoA activity in Huh-7 hepatocellular carcinoma cells
      Title: A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells.
    3. A cell cycle-regulated reduction in endogenous p190 levels is linked to completion of cytokinesis and generation of viable cell progeny.
      Title: p190RhoGAP is cell cycle regulated and affects cytokinesis.
    4. precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development
      Title: P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001164.1 NP_002881.1 RASA1    BIND  PubMed GAP interacts with p190. This interaction was modeled on a demonstrated interaction between human GAP and rat p190. 
    Q13017 P08648 ITGA5    HPRD  PubMed  
    Q13017 P05556 ITGB1    HPRD  PubMed  
    Q13017 Q14289 PTK2B    HPRD  PubMed  
    Q13017 Q99952 PTPN18    HPRD  PubMed  
    Q13017 P20936 RASA1    HPRD  PubMed  
    Q13017 P61587 RND3    HPRD  PubMed  
    Q13017 Q9HAU4 SMURF2    HPRD  PubMed  
    BioGRID:106887 BioGRID:111787 PXN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106887 BioGRID:106880 RHOA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106887 BioGRID:118113 RND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106887 BioGRID:113810 RND2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106887 BioGRID:106883 RND3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106887 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RAC1 signaling pathway, organism-specific biosystem
      RAC1 signaling pathway
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Rho GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    GTP catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of Rho GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    rho GTPase-activating protein 5
    Names
    rho GTPase-activating protein 5
    p105 RhoGAP
    growth factor independent 2
    p100 RasGAP-associated p105 protein
    rho-type GTPase-activating protein 5
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030055.1 → NP_001025226.1  rho GTPase-activating protein 5 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL045112, AL161665, BC050059
      Consensus CDS
      CCDS32062.1
      UniProtKB/Swiss-Prot
      Q13017
      Related
      ENSP00000371897, ENST00000345122
      Conserved Domains (4) summary
      cd04373
      Location:1260 – 1444
      Blast Score: 829
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      smart00324
      Location:1272 – 1445
      Blast Score: 557
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      cl02610
      Location:429 – 481
      Blast Score: 130
      FF; FF domain
      cl09099
      Location:31 – 246
      Blast Score: 128
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001173.2 → NP_001164.2  rho GTPase-activating protein 5 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is one aa shorter compared to isoform a.
      Source sequence(s)
      AL045112, AL161665, CA945100
      Consensus CDS
      CCDS45095.1
      UniProtKB/Swiss-Prot
      Q13017
      Related
      ENSP00000393307, ENST00000432921
      Conserved Domains (4) summary
      cd04373
      Location:1259 – 1443
      Blast Score: 829
      RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
      smart00324
      Location:1271 – 1444
      Blast Score: 557
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      cl02610
      Location:429 – 481
      Blast Score: 130
      FF; FF domain
      cl09099
      Location:31 – 246
      Blast Score: 128
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      32546495..32628934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      12663810..12746250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL161665.5 (62761..145201) None
    genomic CH471078.2 EAW65935.1
      EAW65936.1
      EAW65937.1
      EAW65938.1
    mRNA AB209751.1 BAD92988.1
    mRNA AK023468.1 None
    mRNA AK292966.1 BAF85655.1
    mRNA AK307454.1 None
    mRNA AL045112.1 None
    mRNA AY316523.1 AAP83192.1
    mRNA BC032723.2 AAH32723.1
    mRNA BC050059.1 AAH50059.1
    mRNA BC075799.1 AAH75799.1
    mRNA BC129928.1 AAI29929.1
    mRNA BC129929.1 AAI29930.1
    mRNA CA945100.1 None
    mRNA U17032.1 AAA95963.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13017.2 GenPept UniProtKB/Swiss-Prot:Q13017
    Q7Z2X2 GenPept UniProtKB/TrEMBL:Q7Z2X2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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