prkacba protein kinase, cAMP-dependent, catalytic, beta a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkacbaprovided by ZNC
Official Full Name: protein kinase, cAMP-dependent, catalytic, beta aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1351
See related: Ensembl:ENSDARG00000001782 AllianceGenome:ZFIN:ZDB-GENE-040426-1351
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Prkacb; zgc:64054
Summary: Predicted to enable AMP-activated protein kinase activity; ATP binding activity; and cAMP-dependent protein kinase activity. Predicted to be involved in protein kinase A signaling. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Is expressed in several structures, including brain; fin bud; hatching gland; optic cup; and retinal neural layer. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (8129777..8150894)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (8119938..8141055)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase, cAMP-dependent, catalytic, beta a

NP_957317.1

EC 2.7.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201023.1 → NP_957317.1 protein kinase, cAMP-dependent, catalytic, beta a

See identical proteins and their annotated locations for NP_957317.1

Status: PROVISIONAL

Source sequence(s)

BC053227

UniProtKB/TrEMBL

A0A0R4IZM2, F6NVZ0, Q7T374

Related

ENSDARP00000023805.8, ENSDART00000011183.9

Conserved Domains (2) summary

PTZ00426
Location:68 → 379

PTZ00426; cAMP-dependent protein kinase catalytic subunit; Provisional

cd14209
Location:86 → 375

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase