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    rols rolling pebbles [ Drosophila melanogaster ]

    Gene ID: 39368, updated on 10-May-2012
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    Summary

    Official Symbol
    rolsprovided by Flybase
    Official Full Name
    rolling pebblesprovided by Flybase
    Primary source
    FLYBASE:FBgn0041096
    Locus tag
    Dmel_CG32096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0257455.19; ants; Ants; ANTS; ants/rols; CG12277; CG17155; CG32096; CG5679; Dmel\CG32096; l(3)08232; l(3)68Fd; l(3)j2A6; Rol/Ants; Rols; Rols7; rols\ants
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    Genomic context

    Location :
    68F1-68F1
    Sequence :
    Chromosome: 3L; NT_037436.3 (12001315..12057959, complement)
    See rols in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG5684 gene product from transcript CG5684-RA Neighboring gene CG6928 gene product from transcript CG6928-RB Neighboring gene CG6793 gene product from transcript CG6793-RA Neighboring gene Semaphorin-5c Neighboring gene CG17154 gene product from transcript CG17154-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner. Bulchand S, et al. PLoS One, 2010 Feb 23. PMID 20186342.
    2. Affinity Density: a novel genomic approach to the identification of transcription factor regulatory targets. Hazelett DJ, et al. Bioinformatics, 2009 Jul 1. PMID 19401399.
    3. Mind bomb 2, a founder myoblast-specific protein, regulates myoblast fusion and muscle stability. Carrasco-Rando M, et al. Development, 2008 Mar. PMID 18216171.
    4. SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion. Richardson BE, et al. Development, 2007 Dec. PMID 18003739.
    5. Signalling pathways involved in adult heart formation revealed by gene expression profiling in Drosophila. Zeitouni B, et al. PLoS Genet, 2007 Oct. PMID 17937502.

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
      Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
    2. Genetic interaction of rols6, myoblast city protein, and rac GTP-binding proteins might lead to proper Malpighian tubule morphology.
      Title: In Drosophila melanogaster, the rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology.
    3. This implicates the Duf-Rols7 positive feedback loop to the occurrence of fusion at specific sites along the membrane and provides a mechanism by which the rate of fusion is controlled.
      Title: A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila.
    4. In summary, these data show that besides the role in myoblast fusion, Rols7 is a scaffold protein during myofibrillogenesis and in the Z-line of the sarcomere as well as in the terminal Z-disc linking the muscle to the epidermal attachment sites.
      Title: Drosophila rolling pebbles colocalises and putatively interacts with alpha-Actinin and the Sls isoform Zormin in the Z-discs of the sarcomere and with Dumbfounded/Kirre, alpha-Actinin and Zormin in the terminal Z-discs.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:64728 BioGRID:65890 Atu    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:65646 CG11306    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:58732 CG11581    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:63774 CG12025    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:62265 CG13333    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:61370 CG1416    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:66523 CG14711    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:62864 CG15118    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:64799 CG17666    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:66488 CG17721    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:61826 CG30000    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:77400 CG31510    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:57731 CG3621    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:63444 CG4065    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:58946 CG4239    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:67527 CG6800    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:61736 CG8229    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:66350 CG8417    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:58936 CG9917    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:68683 Ppn    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:57577 RpL36    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:68230 RpL4    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:68919 RpL8    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:67562 SKIP    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:66106 Sp7    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:63557 Tina-1    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:60327 Tsp29Fb    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:58375 Yp1    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:71314 alphaTry    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:62900 betaTub56D    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:62670 eIF3-S9    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:68718 jim    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:57822 kirre    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:64728 BioGRID:67754 mbc    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:64728 BioGRID:66233 pyd    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:70563 qsm    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:66822 spn-B    BioGRID  PubMed Two-hybrid 
    BioGRID:64728 BioGRID:66026 zen    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    myoblast fusion NAS
    Non-traceable Author Statement
    more info
    		  
    myoblast fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG32096 gene product from transcript CG32096-RB
    Names
    CG32096-PA
    CG32096-PB
    CG32096-PC
    CG32096-PD
    CG32096-PE
    antisocial
    rolling pebbles
    rolling pebbles 7
    rols-PA
    rols-PB
    rols-PC
    rols-PD
    rols-PE
    NP_729778.1
    • unusual splice
    NP_729780.1
    • unusual splice
    NP_729781.1
    • unusual splice
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      12001315..12057959, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168487.1 → NP_729778.1  rolling pebbles, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTS9
      Related
      FBpp0075785, FBtr0076053
      Conserved Domains (4) summary
      cd00189
      Location:1734 – 1843
      Blast Score: 117
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      cd00204
      Location:1549 – 1675
      Blast Score: 261
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1559 – 1652
      Blast Score: 219
      Ank_2; Ankyrin repeats (3 copies)
      cl15348
      Location:327 – 364
      Blast Score: 87
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_140285.2 → NP_648542.1  rolling pebbles, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTS8
      Related
      FBpp0075786, FBtr0076054
      Conserved Domains (4) summary
      cd00189
      Location:1403 – 1512
      Blast Score: 116
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      cd00204
      Location:1218 – 1344
      Blast Score: 260
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1228 – 1321
      Blast Score: 217
      Ank_2; Ankyrin repeats (3 copies)
      cl15348
      Location:97 – 134
      Blast Score: 85
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_168490.1 → NP_729781.1  rolling pebbles, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTS6
      Related
      FBpp0075787, FBtr0076055
      Conserved Domains (4) summary
      cd00189
      Location:1504 – 1613
      Blast Score: 116
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      cd00204
      Location:1319 – 1445
      Blast Score: 258
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1329 – 1422
      Blast Score: 217
      Ank_2; Ankyrin repeats (3 copies)
      cl15348
      Location:97 – 134
      Blast Score: 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    4. NM_168488.1 → NP_729779.1  rolling pebbles, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTS8
      Related
      FBpp0075788, FBtr0076056
      Conserved Domains (4) summary
      cd00189
      Location:1403 – 1512
      Blast Score: 116
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      cd00204
      Location:1218 – 1344
      Blast Score: 260
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1228 – 1321
      Blast Score: 217
      Ank_2; Ankyrin repeats (3 copies)
      cl15348
      Location:97 – 134
      Blast Score: 85
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    5. NM_168489.1 → NP_729780.1  rolling pebbles, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTS6
      Related
      FBpp0075789, FBtr0076057
      Conserved Domains (4) summary
      cd00189
      Location:1504 – 1613
      Blast Score: 116
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      cd00204
      Location:1319 – 1445
      Blast Score: 258
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:1329 – 1422
      Blast Score: 217
      Ank_2; Ankyrin repeats (3 copies)
      cl15348
      Location:97 – 134
      Blast Score: 86
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAF49967.2
    genomic AE014296.4 AAN12250.1
    mRNA AY058388.1 AAL13617.1
    mRNA AF440569.1 AAL30171.1
    genomic AE014296.4 AAF49968.2
    mRNA AF440568.1 AAL30170.1
    genomic AE014296.4 AAN12251.1
    genomic AE014296.4 AAF49970.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTS9.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content