LCN2 lipocalin 2 [Homo sapiens] - Gene

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Summary

Official Symbol: LCN2provided by HGNC
Official Full Name: lipocalin 2provided by HGNC
Primary source: HGNC:6526
Locus tag: RP11-395P17.6
See related: Ensembl:ENSG00000148346; HPRD:02551; MIM:600181; Vega:OTTHUMG00000020734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 24p3; MSFI; NGAL

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Genomic context

Location :: 9q34

Sequence :: Chromosome: 9; NC_000009.11 (130911732..130915734)

See LCN2 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NGAL protein seems to represent a marker of malignant follicular cell-derived thyroid tumors, and especially of those with follicular architecture.
Title: Neutrophil gelatinase-associated lipocalin (NGAL) immunohistochemical expression in follicular cell-derived thyroid tumors: a novel diagnostic tool?
Baseline urinary NGAL is not associated with the decline in glomerular filtration rate or disease progression in patients with type 1 diabetes and diabetic nephropathy.
Title: Urinary neutrophil gelatinase-associated lipocalin and progression of diabetic nephropathy in type 1 diabetic patients in a four-year follow-up study.
NGAL is up-regulated in patients with endometrial hyperplasia to prevent the transition from hyperplasia to carcinoma.
Title: The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia.
PCOS per se is not associated with elevated lipocalin-2 levels. Weight loss induces a significant reduction in lipocalin-2 levels in overweight/obese patients with PCOS.
Title: Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome.
the immunohistochemical detection of NGAL may be helpful in the differential diagnosis between malignant and benign follicular-patterned lesions of the thyroid
Title: Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) immunoexpression in follicular-patterned lesions of the thyroid gland.
Lipocalin 2 is not an independent predictor of metabolic and cardiovascular risk factors in young men cross-sectionally or prospectively.
Title: Circulating lipocalin 2 is associated with body fat distribution at baseline but is not an independent predictor of insulin resistance: the prospective Cyprus Metabolism Study.
siderocalin Q83 exhibits differential slow dynamics upon ligand binding that we characterized by relaxation dispersion experiments.
Title: Siderocalin Q83 exhibits differential slow dynamics upon ligand binding.
Increased plasma LCN2 levels during mild cognitive impairment (MCI) could be helpful in predicting the progression from MCI to Alzheimer's disease.
Title: Increased plasma levels of lipocalin 2 in mild cognitive impairment.
NGAL prevents renal hypoxia/reoxygenation injury via inhibition of apoptosis by reducing the expression of Bax, Bcl-2, and caspase-3.
Title: Protective effects of neutrophil gelatinase-associated lipocalin on hypoxia/reoxygenation injury of HK-2 cells.
Confirmed that density of NGAL expressing neutrophils in CCRCC was associated with poor outcome.
Title: [The neutrophil gelatinase-associated lipocalin, or LCN 2, marker of aggressiveness in clear cell renal cell carcinoma].

Submit: New GeneRIF Correction See all (179)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P80188	P14210	HGF	HPRD	PubMed
P80188	P80188	LCN2	HPRD	PubMed
P80188	P98164	LRP2	HPRD	PubMed
P80188	P08253	MMP2	HPRD	PubMed
P80188	P14780	MMP9	HPRD	PubMed
BioGRID:110126	BioGRID:110126	LCN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110126	BioGRID:110457	MMP2	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
innate immune response	ISS Inferred from Sequence or Structural Similarity more info
ion transport	IEA Inferred from Electronic Annotation more info
iron ion homeostasis	IEA Inferred from Electronic Annotation more info
regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
siderophore transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
extracellular region	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: neutrophil gelatinase-associated lipocalin

Names: neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; siderocalin; oncogene 24p3; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005564.3 → NP_005555.2 neutrophil gelatinase-associated lipocalin precursor

Status: VALIDATED

Source sequence(s)

BC033089, BM977724, BP272828

Consensus CDS

CCDS6892.1

UniProtKB/Swiss-Prot

P80188

Related

ENSP00000277480, OTTHUMP00000022238, ENST00000277480, OTTHUMT00000054373

Conserved Domains (1) summary

cl01150
Location:48 – 193
Blast Score: 241

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

130911732..130915734

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

100525402..100529404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL590708.18	CAI13823.1
		CAI13824.1
genomic	CH471090.1	EAW87748.1
		EAW87749.1
		EAW87750.1
genomic	X99133.1	CAA67574.1
mRNA	AK301694.1	BAG63166.1
mRNA	AK316217.1	BAH14588.1
mRNA	AW778875.1	None
mRNA	BC033089.1	AAH33089.1
mRNA	BF354583.1	None
mRNA	BM977724.1	None
mRNA	BP272828.1	None
mRNA	BX644845.1	None
mRNA	CA454137.1	None
mRNA	CR542092.1	CAG46889.1
mRNA	EU644752.1	ACD02429.1
mRNA	N79823.1	None
mRNA	S75256.1	AAD14168.1
mRNA	X83006.1	CAA58127.1