STMN1 stathmin 1 [Homo sapiens] - Gene

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Summary

Official Symbol: STMN1provided by HGNC
Official Full Name: stathmin 1provided by HGNC
Primary source: HGNC:6510
Locus tag: RP1-125I3.5
See related: Ensembl:ENSG00000117632; HPRD:01047; MIM:151442; Vega:OTTHUMG00000007389
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215; FLJ32206; MGC138869; MGC138870
Summary: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

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Genomic context

Location :: 1p36.11

Sequence :: Chromosome: 1; NC_000001.10 (26210677..26233368, complement)

See STMN1 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Potentially, modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
Title: LRRC4 inhibits the proliferation of human glioma cells by modulating the expression of STMN1 and microtubule polymerization.
Data show that low levels of Siva1 and Ser16-phosphorylated stathmin correlate with high metastatic states of breast cancer cells.
Title: Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Stathmin immunohistochemical staining identifies endometrial carcinomas with lymph node metastases and poor survival.
Title: Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer.
A functional impact of STMN1 on cognitive and affective control processes, is reported.
Title: Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study.
suppression of stathmin is biologically important for megakaryocyte maturation and platelet production
Title: Down-regulation of stathmin expression is required for megakaryocyte maturation and platelet production.
There was significant difference in expression of stathmin gene between laryngeal squamous cell carcinoma tissue and normal tissue.
Title: [The expression stathmin gene in laryngeal squamous cell carcinoma].
These results provide evidence that stathmin-1 expression in uNK cells at the maternal-fetal interface may help modulate uterine natural killer cell function and may be beneficial for a successful pregnancy.
Title: Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion.
Data indicate that stathmin is a target of the PI3K/Akt pathway in cervical cancer cells.
Title: Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway.
The rs182455 polymorphism of stathmin does not influence multiple sclerosis susceptibility or clinical disease course.
Title: Analysis of the stathmin rs182455 single nucleotide promoter polymorphism in patients with multiple sclerosis.
The expression levels of stathmin gene and protein were significantly higher in laryngeal squamous cell carcinoma than those in normal laryngeal tissues.
Title: [Expression of stathmin mRNA and protein in laryngeal squamous cell carcinoma and its clinical implication].

Submit: New GeneRIF Correction See all (60)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005554.1	NP_004055.1	CDKN1B	BIND	PubMed	p27 interacts with stathmin.
P16949	P06493	CDK1	HPRD	PubMed
P16949	P46527	CDKN1B	HPRD	PubMed
P16949	P68400	CSNK2A1	HPRD	PubMed
P16949	P11021	HSPA5	HPRD	PubMed
P16949	P11142	HSPA8	HPRD	PubMed
P16949	P27361	MAPK3	HPRD	PubMed
P16949	P17612	PRKACA	HPRD	PubMed
P16949	P40763	STAT3	HPRD	PubMed
P16949	Q9NRR5	UBQLN4	HPRD	PubMed
P16949	Q8TAS1	UHMK1	HPRD	PubMed
BioGRID:110119	BioGRID:109544	HSPA8	BioGRID	PubMed	Reconstituted Complex
BioGRID:110119	BioGRID:200078	Hspa5	BioGRID	PubMed	Two-hybrid
BioGRID:110119	BioGRID:198540	Rb1cc1	BioGRID	PubMed	Two-hybrid
BioGRID:110119	BioGRID:110812	SEPT2	BioGRID	PubMed	Two-hybrid
BioGRID:110119	BioGRID:113075	TRPC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110119	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110119	BioGRID:200956	Uhmk1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
signal transducer activity	TAS Traceable Author Statement more info	PubMed
tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
mitotic spindle organization	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info
response to virus	IEP Inferred from Expression Pattern more info	PubMed
signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
intracellular	IDA Inferred from Direct Assay more info	PubMed
intracellular	TAS Traceable Author Statement more info	PubMed
microtubule	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: stathmin

Names: stathmin; prosolin; metablastin; oncoprotein 18; phosphoprotein 19; phosphoprotein p19; stathmin 1/oncoprotein 18; transmembrane protein C1orf215; leukemia-associated phosphoprotein p18

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145454.1 → NP_001138926.1 stathmin isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the longest transcript, and encodes the longer isoform (b).

Source sequence(s)

AK303692, AV714035, BC028398, BC114502, BG493669

Consensus CDS

CCDS44090.1

UniProtKB/Swiss-Prot

P16949

Related

ENSP00000410452, OTTHUMP00000230726, ENST00000426559, OTTHUMT00000385768

Conserved Domains (1) summary

pfam00836
Location:4 – 126
Blast Score: 416

Stathmin; Stathmin family
NM_005563.3 → NP_005554.1 stathmin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK054594, BF686314, BG030679, BQ772197

Consensus CDS

CCDS269.1

UniProtKB/Swiss-Prot

P16949

Related

ENSP00000387858, OTTHUMP00000008527, ENST00000455785, OTTHUMT00000019355

Conserved Domains (1) summary

pfam00836
Location:4 – 143
Blast Score: 344

Stathmin; Stathmin family
NM_203399.1 → NP_981944.1 stathmin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK054594, BG030679, BM563894, BQ772197

Consensus CDS

CCDS269.1

UniProtKB/Swiss-Prot

P16949

Related

ENSP00000350531, OTTHUMP00000008528, ENST00000357865, OTTHUMT00000019357

Conserved Domains (1) summary

pfam00836
Location:4 – 143
Blast Score: 344

Stathmin; Stathmin family
NM_203401.1 → NP_981946.1 stathmin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK054594, BG030679, BQ428400, BQ772197

Consensus CDS

CCDS269.1

UniProtKB/Swiss-Prot

P16949

Related

ENSP00000382633, ENST00000399728

Conserved Domains (1) summary

pfam00836
Location:4 – 143
Blast Score: 344

Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

26210677..26233368, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

24466602..24489287, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152497.1: Suppressed sequence

Description

NM_152497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL033528.20	CAC16020.1
		CAM12864.1
		CAM12865.1
genomic	AL033528.20	CAC16020.1
		CAM12864.1
		CAM12865.1
genomic	CH471059.2	EAX07854.1
		EAX07855.1
		EAX07856.1
		EAX07857.1
		EAX07858.1
		EAX07859.1
		EAX07860.1
		EAX07861.1
genomic	CH471059.2	EAX07854.1
		EAX07855.1
		EAX07856.1
		EAX07857.1
		EAX07858.1
		EAX07859.1
		EAX07860.1
		EAX07861.1
genomic	M31303.1	AAA59971.1
genomic	X94912.1	CAA64398.1
mRNA	AB209282.1	BAD92519.1
mRNA	AB451319.1	BAG70133.1
mRNA	AB451448.1	BAG70262.1
mRNA	AK054594.1	None
mRNA	AK056768.1	BAB71277.1
mRNA	AK303692.1	BAH14020.1
mRNA	AK311801.1	BAG34744.1
mRNA	AV714035.1	None
mRNA	BC014353.1	AAH14353.1
mRNA	BC023313.1	None
mRNA	BC028398.1	None
mRNA	BC082228.1	AAH82228.1
mRNA	BC114443.1	AAI14444.1
mRNA	BC114502.1	AAI14503.1
mRNA	BF686314.1	None
mRNA	BG030679.1	None
mRNA	BG493669.1	None
mRNA	BM563894.1	None
mRNA	BQ428400.1	None
mRNA	BQ772197.1	None
mRNA	BX647885.1	None
mRNA	D28428.1	BAA05794.1
mRNA	J04991.1	AAA59980.1
mRNA	X53305.1	CAA37391.1
mRNA	Z11566.1	CAA77660.1
other-genetic	AM392854.1	CAL37732.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P16949.3	GenPept	UniProtKB/Swiss-Prot:P16949
Q59G27	GenPept	UniProtKB/TrEMBL:Q59G27
Q96CE4	GenPept	UniProtKB/TrEMBL:Q96CE4