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    klu klumpfuss [ Drosophila melanogaster ]

    Gene ID: 39228, updated on 4-Feb-2012
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    Summary

    Official Symbol
    kluprovided by Flybase
    Official Full Name
    klumpfussprovided by Flybase
    Primary source
    FLYBASE:FBgn0013469
    Locus tag
    Dmel_CG12296
    Gene type
    protein coding
    RNA name
    klumpfuss
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12296; Dmel\CG12296; Klu; l(3)09036; l(3)10052; P09036
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    Genomic context

    Location :
    68A1-68A1
    Sequence :
    Chromosome: 3L; NT_037436.3 (10974826..11001924, complement)
    See klu in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG34050 gene product from transcript CG34050-RA Neighboring gene CG14147 gene product from transcript CG14147-RA Neighboring gene ncRNA Neighboring gene CG32079 gene product from transcript CG32079-RB Neighboring gene CG7923 gene product from transcript CG7923-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS. Benito-Sipos J, et al. Development, 2010 Oct. PMID 20823069.
    2. The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Parrish JZ, et al. Neuron, 2009 Sep 24. PMID 19778508.
    3. Characteristics of genes up-regulated and down-regulated after 24 h starvation in the head of Drosophila. Fujikawa K, et al. Gene, 2009 Oct 1. PMID 19573582.
    4. Klumpfuss is involved in the determination of sensory organ precursors in Drosophila. Kaspar M, et al. Dev Biol, 2008 Dec 15. PMID 18831969.
    5. Hairless induces cell death by downregulation of EGFR signalling activity. Protzer CE, et al. J Cell Sci, 2008 Oct 1. PMID 18765565.

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. show that the products of the genes klumpfuss, nab and castor play important roles in their specification via a genetic cascade
      Title: A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS.
    2. Klumpfuss is a zinc finger transcription factor that acts as a repressor of transcription to promote sensory organ precursor cell formation and regulates proneural proteins.
      Title: Klumpfuss is involved in the determination of sensory organ precursors in Drosophila.
    3. klumpfuss is required and differentially expressed in the cells that choose the life or death cell fate during normal cell fate selection in Drosophila retina
      Title: klumpfuss regulates cell death in the Drosophila retina.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:64605 BioGRID:57554 ac    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    nucleic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    CG12296 gene product from transcript CG12296-RA
    Names
    CG12296-PA
    klu-PA
    klumpfuss
    klumphuss
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      10974826..11001924, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057714.3 → NP_477062.1  klumpfuss [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTD3
      Related
      FBpp0075976, FBtr0076247
      Conserved Domains (2) summary
      pfam13465
      Location:640 – 665
      Blast Score: 101
      zf-H2C2_2; Zinc-finger double domain
      cl15478
      Location:627 – 648
      Blast Score: 78
      zf-C2H2; Zinc finger, C2H2 type
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAF50119.2
    mRNA BT025225.1 ABF17916.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q9VTD3.1 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content