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simj simjang [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39212, updated on 27-Mar-2024

Summary

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Official Symbol
simjprovided by FlyBase
Official Full Name
simjangprovided by FlyBase
Primary source
FLYBASE:FBgn0010762
Locus tag
Dmel_CG32067
See related
AllianceGenome:FB:FBgn0010762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.361; CG32067; CG7983; CG8000; Dmel\CG32067; dp66; l(3)01814; l(3)j4A5; l(3)rN672; p66; p66/68; p66/68-like; SIMJ
Summary
Involved in several processes, including cardiac cell fate specification; habituation; and positive regulation of synaptic assembly at neuromuscular junction. Located in nucleus. Part of NuRD complex. Is expressed in organism. Used to study intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 18. Orthologous to several human genes including GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See simj in Genome Data Viewer
Location:
67E6-67E6; 3-33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10664739..10690734)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10657839..10683834)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Acireductone dioxygenase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa B subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity. Chou HY, et al. J Biomed Sci, 2014 Jul 19. PMID 25037729, Free PMC Article
  2. GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila. Willemsen MH, et al. J Med Genet, 2013 Aug. PMID 23644463
  3. De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations. Dias KR, et al. Genet Med, 2022 Sep. PMID 35916866
  4. Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. Lenz J, et al. PLoS Genet, 2021 Feb. PMID 33600407, Free PMC Article
  5. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal knockdown of Drosophila GATAD2B orthologue, simj, resulted in impaired learning and altered synapse morphology
    Title: GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila.
  2. p66 is associated with the Mi-2/NURD complex and has developmental roles in Drosophila
    Title: Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 10668518-10668552 mobile_element_type = transposon:1731{}2231

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in habituation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
simjang
Names
CG32067-PA
CG32067-PB
CG32067-PC
CG32067-PD
CG32067-PE
simj-PA
simj-PB
simj-PC
simj-PD
simj-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10664739..10690734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274756.1 → NP_001261685.1  simjang, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261685.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF79
    Conserved Domains (1) summary
    pfam16563
    Location:185 → 222
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  2. NM_001274755.1 → NP_001261684.1  simjang, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PET3
    Conserved Domains (1) summary
    pfam16563
    Location:185 → 222
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  3. NM_168420.2 → NP_729624.1  simjang, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8G1
    Related
    FBpp0075992
    Conserved Domains (1) summary
    pfam16563
    Location:185 → 222
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  4. NM_140150.3 → NP_648407.1  simjang, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960V1
    Related
    FBpp0075993
    Conserved Domains (1) summary
    pfam16563
    Location:185 → 222
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  5. NM_168421.2 → NP_729625.1  simjang, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729625.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8G1
    Related
    FBpp0075991
    Conserved Domains (1) summary
    pfam16563
    Location:185 → 222
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PET3 M9PET3
M9PF79 M9PF79
Q0E8G1 Q0E8G1
Q960V1 Q960V1

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