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    ARHGAP1 Rho GTPase activating protein 1 [ Homo sapiens ]

    Gene ID: 392, updated on 11-May-2012
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    Summary

    Official Symbol
    ARHGAP1provided by HGNC
    Official Full Name
    Rho GTPase activating protein 1provided by HGNC
    Primary source
    HGNC:673
    See related
    Ensembl:ENSG00000175220; HPRD:04108; MIM:602732; Vega:OTTHUMG00000166567
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RHOGAP; RHOGAP1; CDC42GAP; p50rhoGAP
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    Genomic context

    Location :
    11p11.2
    Sequence :
    Chromosome: 11; NC_000011.9 (46698630..46722120, complement)
    See ARHGAP1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene ATG13 autophagy related 13 homolog (S. cerevisiae) Neighboring gene zinc finger protein 408 Neighboring gene coagulation factor II (thrombin)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth. Kurooka T, et al. J Biol Chem, 2011 Feb 25. PMID 21169361.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study. vom Dorp F, et al. Urol Int, 2011. PMID 21051874.

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Rho proteins and ROK play a pivotal role in this signaling cascade
      Title: Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.
    2. PA and Rap1 cooperatively regulate RA-RhoGAP activity for promoting neurite outgrowth.
      Title: Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutation of ARHGAP9 in patients with coronary spastic angina.
    4. The NR5A1 gene expression was activated in mesenchymal stem cells by siRNA directed against RhoGAP (ARHGAP26).
      Title: Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.
    5. ET-1 induces Rho-kinase activation and subsequent phosphorylation of p190A RhoGAP, leading to prolonged RhoA activation.
      Title: Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.
    6. Results show that phorbol-ester-induced activation of protein kinases C and D stimulates association of DLC1 with 14-3-3 adaptor proteins, inhibiting RhoGAP activity and blocking nucleocytoplasmic transfer.
      Title: DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling.
    7. CDC42GAP was identified as a counter-regulatory mediator for tubule formation.
      Title: Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation.
    8. two potential interaction partners of Prx6: the calcium-activated cysteine endopeptidase calpain and the p50RhoGAP protein of the family of Sec14-like proteins.
      Title: [Search for protein-protein interaction partners of peroxiredoxin 6 with the yeast two-hybrid system].
    9. Mutation of three residues of CDC42GAP involved in specific interactions of CDC42GAP with switch domain residues of Cdc42, as well as individual mutations of each of these residues, yields GAPs that are defective in stimulating GTP hydrolysis.
      Title: Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis.
    10. lipopolysaccharide-induced activation of the Rho family GTPase Cdc42, and we show its activation in the human neutrophil to be mediated by a p38 mitogen-activated protein kinase-dependent mechanism.
      Title: Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil.
    Submit: New GeneRIF Correction See all (11)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004299.1 NP_004299.1 ARHGAP1    BIND  PubMed Cdc42GAP interacts with Cdc42GAP. 
    NP_004299.1 NP_004299.1 ARHGAP1    BIND  PubMed Cdc42GAP interacts with itself. 
    NP_004299.1 NP_851852.2 ARHGAP8    BIND  PubMed BPGAP1 interacts with Cdc42GAP. This interaction was modelled on a demonstrated interaction between human BPGAP1 and Cdc42GAP from unspecified source. 
    NP_004299.1 NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with Cdc42GAP. 
    NP_004299.1 NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with Cdc42GAP. 
    NP_004299.1 NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with Cdc42GAP. 
    NP_004299.1 AAK54348.1 BNIPL    BIND  PubMed BNIPL-2 interacts with Cdc42GAP. 
    NP_004299.1 NP_612122.1 BNIPL    BIND  PubMed BNIP-S-alpha interacts with Cdc42GAP. 
    NP_004299.1 CDC42    BIND  PubMed Cdc42GAP interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human Cdc42GAP and Cdc42 from an unspecified species. 
    Q07960 Q07960 ARHGAP1    HPRD  PubMed  
    Q07960 O60241 BAI2    HPRD  PubMed  
    Q07960 Q12982 BNIP2    HPRD  PubMed  
    Q07960 Q7Z465 BNIPL    HPRD  PubMed  
    Q07960 P60953 CDC42    HPRD  PubMed  
    Q07960 Q9H4G0 EPB41L1    HPRD  PubMed  
    Q07960 P04035 HMGCR    HPRD  PubMed  
    Q07960 P08238 HSP90AB1    HPRD  PubMed  
    Q07960 Q14643 ITPR1    HPRD  PubMed  
    Q07960 O60333 KIF1B    HPRD  PubMed  
    Q07960 P27986 PIK3R1    HPRD  PubMed  
    Q07960 Q06124 PTPN11    HPRD  PubMed  
    Q07960 P20936 RASA1    HPRD  PubMed  
    Q07960 P61586 RHOA    HPRD  PubMed  
    Q07960 P08134 RHOC    HPRD  PubMed  
    Q07960 Q6STE5 SMARCD3    HPRD  PubMed  
    Q07960 P12931 SRC    HPRD  PubMed  
    Q07960 Q86VP1 TAX1BP1    HPRD  PubMed  
    Q07960 P68366 TUBA4A    HPRD  PubMed  
    Q07960 P42768 WAS    HPRD  PubMed  
    BioGRID:106885 BioGRID:106885 ARHGAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106885 BioGRID:107131 BNIP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106885 BioGRID:127211 BNIPL    BioGRID  PubMed Two-hybrid 
    BioGRID:106885 BioGRID:107433 CDC42    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106885 BioGRID:111313 PIK3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106885 BioGRID:111817 RAC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106885 BioGRID:106880 RHOA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106885 BioGRID:106882 RHOC    BioGRID  PubMed Two-hybrid 
    BioGRID:106885 BioGRID:112592 SRC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106885 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of CDC42 activity, organism-specific biosystem
      Regulation of CDC42 activity
    • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RAC1 activity, organism-specific biosystem
      Regulation of RAC1 activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Rac GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Rho GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of Rho GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    rho GTPase-activating protein 1
    Names
    rho GTPase-activating protein 1
    p50-RhoGAP
    CDC42 GTPase-activating protein
    GTPase-activating protein rhoOGAP
    rho-type GTPase-activating protein 1
    rho-related small GTPase protein activator
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004308.2 → NP_004299.1  rho GTPase-activating protein 1

      Status: PROVISIONAL

      Source sequence(s)
      BC018118
      Consensus CDS
      CCDS7922.1
      UniProtKB/Swiss-Prot
      Q07960
      Related
      ENSP00000310491, OTTHUMP00000233485, ENST00000311956, OTTHUMT00000390472
      Conserved Domains (3) summary
      cd00170
      Location:72 – 204
      Blast Score: 217
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cd04404
      Location:239 – 431
      Blast Score: 835
      RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...
      smart00324
      Location:258 – 427
      Blast Score: 430
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      46698630..46722120, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      46404670..46428159, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC115088.6 (37600..61090) None
    genomic CH471064.2 EAW67982.1
      EAW67983.1
      EAW67984.1
    mRNA AK126404.1 None
    mRNA AK298562.1 BAG60756.1
    mRNA AK307296.1 None
    mRNA AK310605.1 None
    mRNA BC018118.1 AAH18118.1
    mRNA U02570.1 AAA16142.1
    mRNA U62794.1 AAB66594.1
    mRNA Z23024.1 CAA80560.1
    other-genetic DQ894145.2 ABM85071.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15376 GenPept UniProtKB/TrEMBL:O15376
    Q07960.1 GenPept UniProtKB/Swiss-Prot:Q07960
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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