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    USP17 ubiquitin specific peptidase 17 [ Homo sapiens ]

    Gene ID: 391627, updated on 8-May-2012
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    Summary

    Official Symbol
    USP17provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 17provided by HGNC
    Primary source
    HGNC:12615
    Locus tag
    hCG_1807742
    See related
    MIM:607011
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RS447; USP17A; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M; MGC119330; MGC119331; MGC119333
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    Genomic context

    Location :
    4p15
    Sequence :
    Chromosome: 4; NC_000004.11 (9360109..9361701)
    See USP17 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like Neighboring gene ubiquitin specific peptidase 17-like 6, pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. de la Vega M, et al. Nat Commun, 2011 Mar 29. PMID 21448158.
    2. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. Ramakrishna S, et al. J Biol Chem, 2011 Mar 25. PMID 21239494.
    3. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. McFarlane C, et al. Cancer Res, 2010 Apr 15. PMID 20388806.
    4. The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Chen R, et al. Cell Res, 2010 Jul. PMID 20368735.
    5. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. de la Vega M, et al. J Biol Chem, 2010 Apr 16. PMID 20147298.

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. USP17 has a critical role in cell migration.
      Title: The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
    2. SDS3, being a substrate of USP17, may play an important role in developing a novel therapeutic means to inhibit specific HDAC activities in cancer.
      Title: Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
    3. our findings suggest that USP17 functions through deubiquitination of RIG-I and MDA5 to regulate virus-induced type I IFN signaling
      Title: The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
    4. whereas H-Ras and N-Ras were unable to localize to the plasma membrane in the presence of USP17, K-Ras4b localization was unaffected
      Title: The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.
    5. USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression
      Title: The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:133990 BioGRID:114888 ADAMTS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133990 BioGRID:107154 BTF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133990 BioGRID:111624 LGMN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133990 BioGRID:123829 NACAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133990 BioGRID:122174 SUDS3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:133990 BioGRID:132019 USP17L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133990 BioGRID:134130 USP17L7    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin thiolesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    NP_001099132.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_046416.1 RNA Sequence

      Source sequence(s)
      AC116655

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      9360109..9361701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105662.1: Suppressed sequence

      Description
      NM_001105662.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC116655.7 (209165..210758) None
    genomic CH471069.1 EAW92671.1
    genomic D38378.1 (241..1833) None
    mRNA AF544011.1 AAQ11741.1
    mRNA AF544012.1 AAQ11742.1
    mRNA BC100991.2 None
    mRNA BC100992.2 None
    mRNA BC100993.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WX57.2 GenPept UniProtKB/Swiss-Prot:Q0WX57
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

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