My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    Cdk8 Cyclin-dependent kinase 8 [ Drosophila melanogaster ]

    Gene ID: 39157, updated on 10-May-2012
    Help top of page

    Summary

    Official Symbol
    Cdk8provided by Flybase
    Official Full Name
    Cyclin-dependent kinase 8provided by Flybase
    Primary source
    FLYBASE:FBgn0015618
    Locus tag
    Dmel_CG10572
    Gene type
    protein coding
    RNA name
    Cyclin-dependent kinase 8
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdk8; CDK8; CG10572; DmCdk8; Dmel\CG10572; dTRAP56; p58
    Help top of page

    Genomic context

    Location :
    67C10-67C10
    Sequence :
    Chromosome: 3L; NT_037436.3 (9830185..9831750, complement)
    See Cdk8 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG33205 gene product from transcript CG33205-RC Neighboring gene CG32050 gene product from transcript CG32050-RA Neighboring gene Inhibitor-2 Neighboring gene GTPase-activating protein 1 Neighboring gene CG10809 gene product from transcript CG10809-RA

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Kondo S, et al. Sci Signal, 2011 Jan 4. PMID 21205937.
    3. A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila. Gobert V, et al. Mol Cell Biol, 2010 Jun. PMID 20368357.
    4. Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Wang W, et al. Genetics, 2008 Aug. PMID 18689877.
    5. Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. Berger J, et al. PLoS Genet, 2008 May 30. PMID 18516287.

    See all (34) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture.
      Title: A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.
    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:64544 BioGRID:58653 Bap60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:61499 CG17002    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:65937 CG2017    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:59881 CG3008    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:63658 CG32479    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:60444 CG34159    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:64355 CG7185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:66871 CycC    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:64544 BioGRID:65323 MED11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:63628 MED14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:59479 MED15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:63152 MED16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:67196 MED17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:57686 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:68741 MED20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:63250 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:65902 MED27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:63633 MED30    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:64242 MED4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:69231 MED6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:66432 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:62960 MED8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:67198 Ssdp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:71878 boca    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:65055 brm    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:58490 dsh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:59468 ebi    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:69121 enc    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:69950 ix    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:66996 mor    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:64891 ptip    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64544 BioGRID:68707 skd    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Homology

    • Homologs of the Cdk8 gene: The Cdk8 gene is conserved in human, chimpanzee, , dog, cow, mouse, chicken, zebrafish, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II transcription cofactor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    cyclin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived leg segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic cell cycle G2/M transition DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    sex comb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    CG10572 gene product from transcript CG10572-RA
    Names
    CG10572-PA
    Cdk8-PA
    Cyclin-dependent kinase 8
    NP_536735.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      9830185..9831750, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080487.2 → NP_536735.2  Cyclin-dependent kinase 8 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VT57
      Related
      FBpp0076098, FBtr0076369
      Conserved Domains (2) summary
      cd07842
      Location:19 – 335
      Blast Score: 1559
      STKc_CDK8_like; Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases
      smart00220
      Location:24 – 335
      Blast Score: 604
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAF50197.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT57.2 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content