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LAMA5 laminin subunit alpha 5 [ Homo sapiens (human) ]

Gene ID: 3911, updated on 18-May-2016
Official Symbol
LAMA5provided by HGNC
Official Full Name
laminin subunit alpha 5provided by HGNC
Primary source
HGNC:HGNC:6485
See related
Ensembl:ENSG00000130702 HPRD:03020; MIM:601033; Vega:OTTHUMG00000032908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Orthologs
Location:
20q13.2-q13.3
Exon count:
81
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (62309060..62367320, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60884116..60942368, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 2 Neighboring gene uncharacterized LOC105372707 Neighboring gene adhesion regulating molecule 1 Neighboring gene microRNA 4758 Neighboring gene LAMA5 antisense RNA 1 Neighboring gene uncharacterized LOC105372708 Neighboring gene ribosomal protein S21

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
NHGRI GWA Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

  • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
    Inflammatory Response Pathway, organism-specific biosystem
    Inflammatory Response Pathway
  • Laminin interactions, organism-specific biosystem (from REACTOME)
    Laminin interactions, organism-specific biosystemLaminins are a large family of conserved, multidomain trimeric basement membrane proteins. There are many theoretical trimer combinations but only 18 have been described (Domogatskaya et al. 2012, Mi...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-1-mediated signaling events, organism-specific biosystem
    Syndecan-1-mediated signaling events
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
structural molecule activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
cell recognition NAS
Non-traceable Author Statement
more info
PubMed 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
embryo development NAS
Non-traceable Author Statement
more info
PubMed 
endothelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
focal adhesion assembly NAS
Non-traceable Author Statement
more info
PubMed 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of a polarized epithelium IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basal lamina NAS
Non-traceable Author Statement
more info
PubMed 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
laminin-10 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-10 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-11 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-5 complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
laminin subunit alpha-5
Names
laminin alpha-5 chain
laminin-10 subunit alpha
laminin-11 subunit alpha
laminin-15 subunit alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050626.1 RefSeqGene

    Range
    5009..63261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005560.4NP_005551.3  laminin subunit alpha-5 precursor

    See identical proteins and their annotated locations for NP_005551.3

    Status: REVIEWED

    Source sequence(s)
    AB067494, AF443072, AL354836, BC003355
    Consensus CDS
    CCDS33502.1
    UniProtKB/Swiss-Prot
    O15230
    Related
    ENSP00000252999, OTTHUMP00000031475, ENST00000252999, OTTHUMT00000080014
    Conserved Domains (9) summary
    smart00136
    Location:44298
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:16891818
    LamB; Laminin B domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:33403497
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam04012
    Location:24352695
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:21882451
    Laminin_I; Laminin Domain I
    pfam06009
    Location:26412762
    Laminin_II; Laminin Domain II
    pfam11740
    Location:23482415
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02193
    Location:24222604
    VirB5_like; VirB5 protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    62309060..62367320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528819.1XP_011527121.1  

    Conserved Domains (9) summary
    smart00136
    Location:44298
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:15981727
    LamB; Laminin B domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:32543411
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam04012
    Location:23442604
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:20972360
    Laminin_I; Laminin Domain I
    pfam06009
    Location:25502671
    Laminin_II; Laminin Domain II
    pfam11740
    Location:22572324
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02193
    Location:23312513
    VirB5_like; VirB5 protein family
  2. XM_011528818.1XP_011527120.1  

    Conserved Domains (9) summary
    smart00136
    Location:44298
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:16431772
    LamB; Laminin B domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:32993456
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam04012
    Location:23892649
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:21422405
    Laminin_I; Laminin Domain I
    pfam06009
    Location:25952716
    Laminin_II; Laminin Domain II
    pfam11740
    Location:23022369
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02193
    Location:23762558
    VirB5_like; VirB5 protein family
  3. XM_006723796.2XP_006723859.1  

    Conserved Domains (9) summary
    smart00136
    Location:44298
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:16891818
    LamB; Laminin B domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:33453502
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam04012
    Location:24352695
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:21882451
    Laminin_I; Laminin Domain I
    pfam06009
    Location:26412762
    Laminin_II; Laminin Domain II
    pfam11740
    Location:23482415
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02193
    Location:24222604
    VirB5_like; VirB5 protein family
  4. XM_006723798.2XP_006723861.1  

    Conserved Domains (4) summary
    smart00136
    Location:44298
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:16891818
    LamB; Laminin B domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:744773
    Laminin_EGF; Laminin EGF-like (Domains III and V)

RNA

  1. XR_936532.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    60784876..60843394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)