LAMA5 laminin, alpha 5 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: LAMA5provided by HGNC
Official Full Name: laminin, alpha 5provided by HGNC
Primary source: HGNC:6485
Locus tag: RP11-157P1.6
See related: Ensembl:ENSG00000130702; HPRD:03020; MIM:601033; Vega:OTTHUMG00000032908
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KIAA1907
Summary: Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 20q13.2-q13.3

Sequence :: Chromosome: 20; NC_000020.10 (60884121..60942368, complement)

See LAMA5 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate specific laminin isoforms and integrins in maintenance of human embryonic stem cells pluripotency in feeder-dependent cultures.
Title: Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture.
PDGF-BB is not superior to laminin as a potential marker of advanced CP.
Title: Coordinated increase in serum platelet-derived growth factor-BB and transforming growth factor-β1 in patients with chronic pancreatitis.
Data indicate that the function-blocking antibody against Lu/B-CAM should be useful for not only investigating cell adhesion to laminin alpha5 but also for developing drugs to inhibit sickle cell vaso-occlusion.
Title: An antibody to the lutheran glycoprotein (Lu) recognizing the LU4 blood type variant inhibits cell adhesion to laminin α5.
Cytoplasmic and basement membrane laminin is important in the pathogenesis and invasion of basal cell carcinoma.
Title: An immunohistochemical study of laminin in basal cell carcinoma.
investigated the relation between epithelial-mesenchymal transition criteria and laminin-332 expression in a cell culture model of transforming growth factor beta-1 (TGFbeta1)/epithelial growth factor (EGF) long time co-stimulation.
Title: EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332.
Data suggest that the alpha5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via alpha3/alpha6beta1 and other integrin receptors.
Title: Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors.
Abnormal distribution of laminin alpha1 and laminin alpha5 in glomerular basement membrane is correlated with GBM thickening and splitting in human Alport's syndrome.
Title: [Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome].
LAMA5 rs659822 regulates anthropometric and metabolic traits in elderly people
Title: Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects.
Data provides support for a primary role of laminin-511 and integrin beta-1 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction.
Title: Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.
Data from experiment with peptide fragments suggest laminin alpha5 (and laminin alpha4) may be part of host defense response and may protect tissues from invading pathogens.
Title: Peptides derived from the human laminin alpha4 and alpha5 chains exhibit antimicrobial activity.

Submit: New GeneRIF Correction See all (45)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_005551.3	NP_000085.1	COL7A1	BIND	PubMed	Collagen VII interacts with laminin 5.
O15230	Activating transcription factor 7 interacting protein	ATF7IP	HPRD	PubMed
O15230	P50895	BCAM	HPRD	PubMed
O15230	Q9BSF8	BTBD10	HPRD	PubMed
O15230	Q02388	COL7A1	HPRD	PubMed
O15230	Q14118	DAG1	HPRD	PubMed
O15230	P98095	FBLN2	HPRD	PubMed
O15230	P11047	LAMC1	HPRD	PubMed
O15230	Q16819	MEP1A	HPRD	PubMed
O15230	Q99972	MYOC	HPRD	PubMed
O15230	Q15796	SMAD2	HPRD	PubMed
O15230	Q7L0J3	SV2A	HPRD	PubMed
BioGRID:110105	BioGRID:110237	BCAM	BioGRID	PubMed	Reconstituted Complex
BioGRID:110105	BioGRID:107691	COL7A1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110105	BioGRID:107975	DAG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110105	BioGRID:108493	FBLN2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110105	BioGRID:110387	MEP1A	BioGRID	PubMed	Biochemical Activity
BioGRID:110105	BioGRID:111343	PLAT	BioGRID	PubMed	Reconstituted Complex
BioGRID:110105	BioGRID:111356	PLG	BioGRID	PubMed	Reconstituted Complex
BioGRID:110105	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
integrin binding	IDA Inferred from Direct Assay more info	PubMed
structural molecule activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	NAS Non-traceable Author Statement more info	PubMed
branching involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
cell differentiation	NAS Non-traceable Author Statement more info	PubMed
cell migration	IDA Inferred from Direct Assay more info	PubMed
cell proliferation	NAS Non-traceable Author Statement more info	PubMed
cell recognition	NAS Non-traceable Author Statement more info	PubMed
cilium assembly	IEA Inferred from Electronic Annotation more info
cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
embryo development	NAS Non-traceable Author Statement more info	PubMed
endothelial cell differentiation	NAS Non-traceable Author Statement more info	PubMed
establishment of protein localization in plasma membrane	IEA Inferred from Electronic Annotation more info
focal adhesion assembly	NAS Non-traceable Author Statement more info	PubMed
hair follicle development	IEA Inferred from Electronic Annotation more info
integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
lung development	IEA Inferred from Electronic Annotation more info
morphogenesis of a polarized epithelium	IEA Inferred from Electronic Annotation more info
morphogenesis of embryonic epithelium	IEA Inferred from Electronic Annotation more info
muscle organ development	IEA Inferred from Electronic Annotation more info
neural crest cell migration	IEA Inferred from Electronic Annotation more info
odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
organ morphogenesis	IEA Inferred from Electronic Annotation more info
regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
regulation of cell migration	IEA Inferred from Electronic Annotation more info
regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of embryonic development	IEA Inferred from Electronic Annotation more info
substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
basal lamina	NAS Non-traceable Author Statement more info	PubMed
basement membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
laminin-1 complex	IEA Inferred from Electronic Annotation more info
laminin-10 complex	IDA Inferred from Direct Assay more info	PubMed
laminin-10 complex	TAS Traceable Author Statement more info	PubMed
laminin-11 complex	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: laminin subunit alpha-5

Names: laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005560.3 → NP_005551.3 laminin subunit alpha-5 precursor

Status: REVIEWED

Source sequence(s)

AF443072, Z95636

Consensus CDS

CCDS33502.1

UniProtKB/Swiss-Prot

O15230

Related

ENSP00000252999, OTTHUMP00000031475, ENST00000252999, OTTHUMT00000080014

Conserved Domains (9) summary

cd00055
Location:540 – 583
Blast Score: 141

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3340 – 3497
Blast Score: 260

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:2188 – 2451
Blast Score: 693

Laminin_I; Laminin Domain I

smart00180
Location:494 – 541
Blast Score: 145

EGF_Lam; Laminin-type epidermal growth factor-like domai

cl02548
Location:1689 – 1818
Blast Score: 400

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1577 – 1625
Blast Score: 158

Laminin_EGF; Laminin EGF-like (Domains III and V)

pfam06009
Location:2641 – 2762
Blast Score: 368

Laminin_II; Laminin Domain II

cl02806
Location:44 – 298
Blast Score: 755

Laminin_N; Laminin N-terminal (Domain VI)

cl05000
Location:2386 – 2527
Blast Score: 107

CHASE3; CHASE3 domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

60884121..60942368, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

57659921..57715071, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL354836.13	CAC22310.1
		CAI12295.1
genomic	AL354836.13	CAC22310.1
		CAI12295.1
genomic	CH471077.2	EAW75372.1
		EAW75373.1
		EAW75374.1
mRNA	AB010099.1	BAA31347.1
mRNA	AB011105.1	BAA25459.1
mRNA	AB067494.1	BAB67800.1
mRNA	AF443072.1	AAM12527.1
mRNA	AK074307.1	None
mRNA	BC003355.1	None
mRNA	BC015386.1	None
mRNA	BC085017.1	AAH85017.1
mRNA	Z95636.1	CAB09137.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O15230.8	GenPept	UniProtKB/Swiss-Prot:O15230
O75079	GenPept	UniProtKB/TrEMBL:O75079
Q5JTP4	GenPept	UniProtKB/TrEMBL:Q5JTP4
Q5U4N9	GenPept	UniProtKB/TrEMBL:Q5U4N9