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PLA2G2C phospholipase A2, group IIC [ Homo sapiens (human) ]

Gene ID: 391013, updated on 26-Jun-2015
Official Symbol
PLA2G2Cprovided by HGNC
Official Full Name
phospholipase A2, group IICprovided by HGNC
Primary source
HGNC:HGNC:9032
See related
Ensembl:ENSG00000187980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
See PLA2G2C in Epigenomics, MapViewer
Location:
1p36.12
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (20163991..20175194, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20490484..20501687, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IIF Neighboring gene uncharacterized LOC105376824 Neighboring gene UBXN10 antisense RNA 1 Neighboring gene UBX domain protein 10 Neighboring gene uncharacterized LOC105376825

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish fusion PubMed

Go to the HIV-1, Human Interaction Database

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
putative inactive group IIC secretory phospholipase A2
Names
putative inactive group IIC secretory phospholipase A2
phosphatidylcholine 2-acylhydrolase-like protein GIIC
phospholipase A2, group IIC (possible pseudogene)
NP_001099042.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105572.1NP_001099042.1  putative inactive group IIC secretory phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_001099042.1

    Status: PROVISIONAL

    Source sequence(s)
    Z98257
    UniProtKB/TrEMBL
    J3KMZ3
    Related
    ENSP00000247992, ENST00000247992
    Conserved Domains (1) summary
    cl05417
    Location:22143
    PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    20163991..20175194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    20600161..20611364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)