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    Hsp26 Heat shock protein 26 [ Drosophila melanogaster ]

    Gene ID: 39075, updated on 10-May-2012
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    Summary

    Official Symbol
    Hsp26provided by Flybase
    Official Full Name
    Heat shock protein 26provided by Flybase
    Primary source
    FLYBASE:FBgn0001225
    Locus tag
    Dmel_CG4183
    Gene type
    protein coding
    RNA name
    heat shock protein 26
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    26; 26K; CG4183; Dmel\CG4183; DmHsp26; hsp 26; hsp26; HSP26; small hsp locus 67B
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    Genomic context

    Location :
    67B2-67B2
    Sequence :
    Chromosome: 3L; NT_037436.3 (9369518..9370527, complement)
    See Hsp26 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene Heat shock gene 67Bb Neighboring gene Heat shock protein 22 Neighboring gene CG4461 gene product from transcript CG4461-RA Neighboring gene Heat shock gene 67Ba Neighboring gene ncRNA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. Ren J, et al. Hum Mol Genet, 2011 Sep 1. PMID 21653638.
    3. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136.
    4. Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model. Wang L, et al. J Neurosci, 2011 Feb 23. PMID 21414908.
    5. Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster. Chan YS, et al. Genetics, 2011 May. PMID 21368273.

    See all (211) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Hsp26 overexpression in larva had only a small thermoprotective effect on locomotion and no effect on neural function.
      Title: Tissue-specific targeting of Hsp26 has no effect on heat resistance of neural function in larval Drosophila.
    2. The functional similarities and differences of neuronal expression of hsp26 and hsp27 in adult Drosophila were demonstrated.
      Title: The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila.
    3. Data show that overexpression of either heat-shock proteins 26 or 27 extended the mean lifespan by 30%, and the flies also displayed increased stress resistance.
      Title: Multiple-stress analysis for isolation of Drosophila longevity genes.
    4. GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter.
      Title: GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_523997.1 NP_476978.1 lwr    BIND  PubMed Lwr (DmUbc9) interacts with Hsp26. 
    BioGRID:64470 BioGRID:63031 CG10527    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:65582 CG10566    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64736 CG11534    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:66596 CG12256    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:66384 CG12811    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:59553 CG14341    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:59407 CG14613    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:58384 CG15309    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:58517 CG1561    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:63012 CG15649    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:59639 CG17237    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:72659 CG17776    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:77306 CG31920    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:76608 CG32313    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:59139 CG32549    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64507 CG3306    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64491 CG3434    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:59022 CG4949    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:67611 CG5315    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:63738 CG7967    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:62621 CG8950    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64701 CycA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:61675 Cyp4e2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:68216 Ets98B    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:61625 Hey    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:534173 Hsp22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64472 Hsp23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64473 Hsp27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:71511 Hsp70Aa    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:67574 PSR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:67729 SPE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64113 Tektin-C    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:64448 Tequila    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:59558 Tgt    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:72428 alpha-catenin-related    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:64937 bmm    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:59586 cpb    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:66942 h-cup    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:62421 igl    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:66203 mRpL19    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:67889 nct    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:68673 nej    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:64316 nmo    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:64556 nudE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:61223 ref(2)P    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64470 BioGRID:60129 sip2    BioGRID  PubMed Two-hybrid 
    BioGRID:64470 BioGRID:66700 timeout    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to heat NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG4183 gene product from transcript CG4183-RA
    Names
    CG4183-PA
    Hsp 26
    Hsp26-PA
    heat shock protein 26
    heat shock protein hsp26
    protein 26
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      9369518..9370527, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079273.2 → NP_523997.1  heat shock protein 26 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02517
      Related
      FBpp0076224, FBtr0076496
      Conserved Domains (1) summary
      cd06526
      Location:85 – 163
      Blast Score: 300
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic J01099.1 AAA28636.1
    genomic AH001016.1 AAA28636.1
    genomic AE014296.4 AAF50288.1
    mRNA AY069419.1 AAL39564.1
    genomic X03890.1 CAA27526.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    0905229C.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content