RND3 Rho family GTPase 3 [Homo sapiens] - Gene

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Summary

Official Symbol: RND3provided by HGNC
Official Full Name: Rho family GTPase 3provided by HGNC
Primary source: HGNC:671
See related: Ensembl:ENSG00000115963; HPRD:04233; MIM:602924; Vega:OTTHUMG00000131859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHE; Rho8; RhoE; memB
Summary: This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

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Genomic context

Location :: 2q23.3

Sequence :: Chromosome: 2; NC_000002.11 (151324709..151344180, complement)

See RND3 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors show that enteropathogenic Escherichia coli translocates EspH, which inactivates mammalian RhoGEFs and triggers cytotoxicity.
Title: The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.
the expression of miR-17 was negatively correlated with that of RND3 in colorectal cancer tissues and cells
Title: Up-regulated miR-17 promotes cell proliferation, tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma.
Restoration of RND3 expression or RHOA knockdown attenuated the migratory ability of residual cells without affecting overall cell survival
Title: A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition.
This study identifies RhoE as a direct target for HIF-1 in gastric cancer cells.
Title: Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia.
Upregulation of FOXD3 expression following inhibition of B-RAF and MEK correlates with the downregulation of Rnd3, a Rho GTPase and inhibitor of RhoA-ROCK signaling.
Title: FOXD3 regulates migration properties and Rnd3 expression in melanoma cells.
Data show that the increased invasiveness of tumorigenic cells was associated with reduced expression of Rnd3.
Title: Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells.
RhoE expression in gastric cancer cells was regulated by histone deacetylation, but not by DNA methylation, at the epigenetic level.
Title: Epigenetic modification of RhoE expression in gastric cancer cells.
study demonstrates a novel role for mir-200b in cell cycle progression and identifies RND3 as a novel mir-200b target
Title: MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells.
RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation.
Title: RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation.
Findings implicate Rnd3 as a major suppressor of RhoA-mediated actin cytoskeletal organization and in the acquisition of an invasive melanoma phenotype.
Title: Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.

Submit: New GeneRIF Correction See all (22)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P61587	Q13017	ARHGAP5	HPRD	PubMed
P61587	Q13464	ROCK1	HPRD	PubMed
P61587	Socius	UBXN11	HPRD	PubMed
BioGRID:106883	BioGRID:106887	ARHGAP5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106883	BioGRID:116290	CIT	BioGRID	PubMed	Two-hybrid
BioGRID:106883	BioGRID:111377	PLXNB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106883	BioGRID:112020	ROCK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106883	BioGRID:109072	SFN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106883	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106883	BioGRID:124844	UBXN11	BioGRID	PubMed	Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
GTP catabolic process	TAS Traceable Author Statement more info	PubMed
actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
cell adhesion	TAS Traceable Author Statement more info	PubMed
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Golgi membrane	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: rho-related GTP-binding protein RhoE

Names: rho-related GTP-binding protein RhoE; protein MemB; small GTP binding protein Rho8; ras homolog gene family, member E; rho-related GTP-binding protein Rho8

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001254738.1 → NP_001241667.1 rho-related GTP-binding protein RhoE precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC074097, AC093738, AK313224

UniProtKB/TrEMBL

B2R838

UniProtKB/Swiss-Prot

P61587

Conserved Domains (1) summary

cd04172
Location:19 – 197
Blast Score: 935

Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases
NM_005168.4 → NP_005159.1 rho-related GTP-binding protein RhoE precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC012513, BX460517, CF127383, DC367501

Consensus CDS

CCDS2190.1

UniProtKB/Swiss-Prot

P61587

Related

ENSP00000263895, OTTHUMP00000162684, ENST00000263895, OTTHUMT00000254808

Conserved Domains (1) summary

cd04172
Location:19 – 197
Blast Score: 935

Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

151324709..151344180, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

143221255..143240755, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC074097.6	AAY15014.1
genomic	AC093738.2	AAX88953.1
genomic	CH471058.2	EAX11524.1
		EAX11525.1
		EAX11526.1
		EAX11527.1
		EAX11528.1
mRNA	AF498969.1	AAM21116.1
mRNA	AK298007.1	BAG60312.1
mRNA	AK299731.1	BAG61629.1
mRNA	AK309442.1	None
mRNA	AK313224.1	BAG36035.1
mRNA	AL702945.1	None
mRNA	BC012513.1	AAH12513.1
mRNA	BQ440721.1	None
mRNA	BT006769.1	AAP35415.1
mRNA	BX460517.2	None
mRNA	CF127383.1	None
mRNA	CR542038.1	CAG46835.1
mRNA	CR542070.1	CAG46867.1
mRNA	DC367501.1	None
mRNA	S82240.1	AAB47133.1
mRNA	X95282.1	CAA64603.1
mRNA	X97758.1	CAA66352.1
other-genetic	DQ890665.2	ABM81591.1
other-genetic	DQ890666.2	ABM81592.1
other-genetic	DQ893847.2	ABM84773.1
other-genetic	EU176167.1	ABW03618.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P61587.1	GenPept	UniProtKB/Swiss-Prot:P61587
Q4ZFY0	GenPept	UniProtKB/TrEMBL:Q4ZFY0
Q53RZ3	GenPept	UniProtKB/TrEMBL:Q53RZ3
Q6FGN7	GenPept	UniProtKB/TrEMBL:Q6FGN7
Q6FGR9	GenPept	UniProtKB/TrEMBL:Q6FGR9