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KRT86 keratin 86, type II [ Homo sapiens (human) ]

Gene ID: 3892, updated on 26-Jun-2015
Official Symbol
KRT86provided by HGNC
Official Full Name
keratin 86, type IIprovided by HGNC
Primary source
HGNC:HGNC:6463
See related
Ensembl:ENSG00000170442; HPRD:03567; MIM:601928; Vega:OTTHUMG00000184153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB6; Hb1; MNX; hHb6; KRTHB1; KRTHB6
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
Orthologs
See KRT86 in Epigenomics, MapViewer
Location:
12q13
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (52274631..52309163)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52642892..52702947)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 7, type II Neighboring gene keratin 87 pseudogene Neighboring gene keratin 88 pseudogene Neighboring gene keratin 81, type II Neighboring gene keratin 83, type II Neighboring gene keratin 89 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Beaded hair
MedGen: C0546966 OMIM: 158000 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of keratin 86 (KRT86; KRTHB6) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25176

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
keratin, type II cuticular Hb6
Names
keratin, type II cuticular Hb6
K86
hair keratin K2.11
hard keratin, type II, 6
keratin protein HB6
keratin, hair, basic, 6 (monilethrix)
keratin-86
type II hair keratin Hb6
type-II keratin Kb26

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008086.1 RefSeqGene

    Range
    5001..12299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002284.3NP_002275.1  keratin, type II cuticular Hb6

    See identical proteins and their annotated locations for NP_002275.1

    Status: REVIEWED

    Source sequence(s)
    AC121757, BC069585
    Consensus CDS
    CCDS41785.1
    UniProtKB/Swiss-Prot
    O43790
    Related
    ENSP00000293525, ENST00000293525
    Conserved Domains (2) summary
    pfam00038
    Location:105416
    Filament; Intermediate filament protein
    cl09111
    Location:225340
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    52274631..52309163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268866.3XP_005268923.1  

    Conserved Domains (2) summary
    pfam00038
    Location:182493
    Filament; Intermediate filament protein
    cl09111
    Location:302417
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. XM_011538337.1XP_011536639.1  

    See identical proteins and their annotated locations for XP_011536639.1

    Related
    ENSP00000444533, OTTHUMP00000241597, ENST00000423955, OTTHUMT00000404911
    Conserved Domains (2) summary
    pfam00038
    Location:105416
    Filament; Intermediate filament protein
    cl09111
    Location:225340
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  3. XM_011538338.1XP_011536640.1  

    See identical proteins and their annotated locations for XP_011536640.1

    Conserved Domains (2) summary
    pfam00038
    Location:105416
    Filament; Intermediate filament protein
    cl09111
    Location:225340
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. XM_011538336.1XP_011536638.1  

    See identical proteins and their annotated locations for XP_011536638.1

    Conserved Domains (2) summary
    pfam00038
    Location:105416
    Filament; Intermediate filament protein
    cl09111
    Location:225340
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    52662295..52669596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)