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KRT83 keratin 83 [ Homo sapiens (human) ]

Gene ID: 3889, updated on 3-Aug-2014
Official Symbol
KRT83provided by HGNC
Official Full Name
keratin 83provided by HGNC
Primary source
HGNC:6460
See related
Ensembl:ENSG00000170523; HPRD:09097; MIM:602765; Vega:OTTHUMG00000169632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB3; Hb-3; KRTHB3
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]
See KRT83 in Epigenomics, MapViewer
Location:
12q13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (52314301..52321398, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52708085..52715182, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 88 pseudogene Neighboring gene keratin 86 Neighboring gene keratin 81 Neighboring gene keratin 89 pseudogene Neighboring gene keratin 85

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC141663

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
hair cycle IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
 
keratin filament IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
keratin, type II cuticular Hb3
Names
keratin, type II cuticular Hb3
K83
hHb3
keratin-83
hair keratin K2.10
type-II keratin Kb23
keratin, hair, basic, 3
hard keratin, type II, 3
type II hair keratin Hb3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008352.1 

    Range
    5001..12098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002282.3NP_002273.3  keratin, type II cuticular Hb3

    See proteins identical to NP_002273.3

    Status: REVIEWED

    Source sequence(s)
    AC121757, BC069546
    Consensus CDS
    CCDS8823.1
    UniProtKB/Swiss-Prot
    P78385
    Related
    ENSP00000293670, OTTHUMP00000241740, ENST00000293670, OTTHUMT00000405182
    Conserved Domains (3) summary
    pfam00038
    Location:110421
    Blast Score: 969
    Filament; Intermediate filament protein
    cl12013
    Location:235425
    Blast Score: 86
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19113
    Location:347431
    Blast Score: 89
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    52314301..52321398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268864.1XP_005268921.1  

    Conserved Domains (1) summary
    pfam00038
    Location:110421
    Blast Score: 930
    Filament; Intermediate filament protein

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    49741813..49743633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. AC_000144.1 

    Range
    49751738..49758855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006709960.1XP_006710023.1  

  2. XM_005275721.1XP_005275778.1  

    Conserved Domains (1) summary
    pfam00038
    Location:110421
    Blast Score: 923
    Filament; Intermediate filament protein

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    52674734..52681831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)