SBK1 SH3-binding domain kinase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: SBK1provided by HGNC
Official Full Name: SH3-binding domain kinase 1provided by HGNC
Primary source: HGNC:17699
See related: Ensembl:ENSG00000188322; HPRD:18608; Vega:OTTHUMG00000166066
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Sbk

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Genomic context

Location :: 16p11.2

Sequence :: Chromosome: 16; NC_000016.9 (28303840..28335170)

See SBK1 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that the wide-spread expression pattern of human SBK1 may predict a broad cellular function, and its dysregulation in certain cancers suggests an involvement of the protein in the pathogenesis of human cancers.
Title: Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:132609	BioGRID:124619	FCHSD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:132609	BioGRID:116413	PACSIN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:132609	BioGRID:118896	PACSIN3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:132609	BioGRID:114733	TRIP10	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
brain development	IEA Inferred from Electronic Annotation more info
peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase SBK1

Names: serine/threonine-protein kinase SBK1; SH3-binding kinase 1

NP_001019572.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024401.2 → NP_001019572.1 serine/threonine-protein kinase SBK1

Status: PROVISIONAL

Source sequence(s)

AY874862

Consensus CDS

CCDS32416.1

UniProtKB/Swiss-Prot

Q52WX2

Related

ENSP00000343248, OTTHUMP00000231814, ENST00000341901, OTTHUMT00000387677

Conserved Domains (2) summary

cd00180
Location:59 – 313
Blast Score: 467

PKc; Catalytic domain of Protein Kinases

smart00220
Location:53 – 316
Blast Score: 579

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

28303840..28335170

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

26395062..26426094

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC138904.3 (110921..142251)	None
genomic	CH471145.2	EAW55733.1
mRNA	AL390134.1	None
mRNA	AY874862.2	AAX59898.1
other-genetic	BC172295.1	AAI72295.1