KRT19 keratin 19 [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: KRT19provided by HGNC
Official Full Name: keratin 19provided by HGNC
Primary source: HGNC:6436
See related: Ensembl:ENSG00000171345; HPRD:01007; MIM:148020; Vega:OTTHUMG00000133422
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: K19; CK19; K1CS
Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 17q21.2

Sequence :: Chromosome: 17; NC_000017.10 (39679869..39684641, complement)

See KRT19 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tumors or dysplastic lesions that carry EBV also generally express higher levels of CK19 than those that do not
Title: Oral dysplasia and squamous cell carcinoma: correlation between increased expression of CD21, Epstein-Barr virus and CK19.
This is the first report describing the potential role of serum Cyfra 21.1 as marker of dedifferentiation and resistance to (131)I therapy in patients with advanced thyroid carcinoma.
Title: Serum cytokeratin 19 fragments: a dedifferentiation marker in advanced thyroid cancer.
combined use of CK19, Gal-3, and HBME-1 is of practical value in the diagnosis and differential diagnosis of benign and malignant thyroid nodules
Title: Usefulness of cytokeratin-19, galectin-3, and Hector Battifora mesothelial-1 in the diagnosis of benign and malignant thyroid nodules.
K19 expressed variably in both oral squamous cell carcinoma and squamous intraepithelial neoplasm
Title: Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.
105 cases of thyroid lesions were evaluated to assess the role of HBME-1, cytokeratin-19 (CK-19), galectin-3 in distinguishing benign from malignant thyroid lesions.
Title: Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesions.
lack of expression of CK19 is infrequent in breast cancers, they do occur not only in tumors with a triplenegative or basal-like phenotype but also in breast cancers with a luminal phenotype
Title: Importance of assessing CK19 immunostaining in core biopsies in patients subjected to sentinel node study by OSNA.
positivity rates of CK19 and CK20 in transverse mesocolon were 48.6 and 61.2%, respectively and increased with the depth of tumor invasion
Title: Expression and clinical significance of CK19 and CK20 expressions in transverse mesocolon biopsies from patients with gastric carcinoma.
CK-19 mRNA-positive circulating tumor cells is associated with an increased risk of late relapse and death in patients with operable breast cancer and indicates the presence of chemo-and hormonotherapy-resistant residual disease.
Title: Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: prognostic relevance for late relapse.
SCC, CEA, Cyfra 21-1 and NSE are valuable in the early diagnosis of lung cancer among suspicious nodules in the lung, especially when they were assayed together for one patient.
Title: Utility of squamous cell carcinoma antigen, carcinoembryonic antigen, Cyfra 21-1 and neuron specific enolase in lung cancer diagnosis: a prospective study from China.
Serum CYFRA 21-1 seems to be a marker of advanced- and high-grade urothelial carcinoma of the bladder, useful for monitoring this disease and for predicting the prognosis.
Title: Clinical usefulness of CEA, CA19-9, and CYFRA 21-1 as tumor markers for urothelial bladder carcinoma.

Submit: New GeneRIF Correction See all (96)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
P08727	Q9NYB9	ABI2	HPRD	PubMed
P08727	Q9NTK1	C10orf10	HPRD	PubMed
P08727	Q9BY27	DGCR6L	HPRD	PubMed
P08727	P11532	DMD	HPRD	PubMed
P08727	Q8IYI6	EXOC8	HPRD	PubMed
P08727	O95990	FAM107A	HPRD	PubMed
P08727	O15287	FANCG	HPRD	PubMed
P08727	O14964	HGS	HPRD	PubMed
P08727	P19012	KRT15	HPRD	PubMed
P08727	P04259	KRT6B	HPRD	PubMed
P08727	Q15154	PCM1	HPRD	PubMed
P08727	Q9H307	PNN	HPRD	PubMed
P08727	O60289	SFI1	HPRD	PubMed
P08727	P23258	TUBG1	HPRD	PubMed
P08727	Q8N6Y0	USHBP1	HPRD	PubMed
P08727	Q14966	ZNF638	HPRD	PubMed
BioGRID:110078	BioGRID:115454	ABI2	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:106821	APC	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:116251	C10orf10	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:107788	CRK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:124488	DGCR6L	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:115119	EIF4A3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:127206	EXOC8	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:116341	FAM107A	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:108484	FANCG	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:109315	HDAC1	BioGRID	PubMed	Negative Genetic
BioGRID:110078	BioGRID:114593	HGS	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:109883	ITGA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:110064	KRT15	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:110052	KRT6B	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:110290	MAGOH	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:111139	PCM1	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:119982	PLEKHA5	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:111412	PNN	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110078	BioGRID:111456	POU5F1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110078	BioGRID:115153	SFI1	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110078	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110078	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110078	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:119509	UCHL5	BioGRID	PubMed	Reconstituted Complex
BioGRID:110078	BioGRID:123791	USHBP1	BioGRID	PubMed	Two-hybrid
BioGRID:110078	BioGRID:124189	USP32	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:113255	VCAM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110078	BioGRID:118145	ZNF638	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

Go to the top of the page Help

Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
Signaling mediated by p38-alpha and p38-beta

General gene information

Go to the top of the page Help

Markers

PMC22705P1 (e-PCR)
- UniSTS:272147

RH71340 (e-PCR)
- UniSTS:89044

Genotypes

See KRT19 SNP Geneview Report
See KRT19 SNP Genotype Report
See KRT19 SNP Variation Viewer Report

Homology

Homologs of the KRT19 gene: The KRT19 gene is conserved in chimpanzee, dog, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	IEA Inferred from Electronic Annotation more info
structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed
structural constituent of muscle	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
response to estrogen stimulus	IEP Inferred from Expression Pattern more info	PubMed
sarcomere organization	IDA Inferred from Direct Assay more info	PubMed
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Z disc	IEA Inferred from Electronic Annotation more info
cell periphery	IDA Inferred from Direct Assay more info	PubMed
costamere	IDA Inferred from Direct Assay more info	PubMed
dystrophin-associated glycoprotein complex	IEA Inferred from Electronic Annotation more info
intermediate filament	IEA Inferred from Electronic Annotation more info
sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: keratin, type I cytoskeletal 19

Names: keratin, type I cytoskeletal 19; CK-19; keratin-19; cytokeratin 19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin intermediate filament

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012285.1 RefSeqGene

Range

5001..9773

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002276.4 → NP_002267.2 keratin, type I cytoskeletal 19

Status: REVIEWED

Source sequence(s)

BC007628, BG490639, BP328445, DA068330

Consensus CDS

CCDS11399.1

UniProtKB/Swiss-Prot

P08727

Related

ENSP00000355124, OTTHUMP00000164620, ENST00000361566, OTTHUMT00000257285

Conserved Domains (1) summary

pfam00038
Location:79 – 388
Blast Score: 1010

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

39679869..39684641, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

35443484..35448259, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

40467401..40472174, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01031810.1 (4894..9669)	None
genomic	AC019349.28 (69754..74519)	None
genomic	AF202321.1	AAF27048.1
genomic	AMYH01008387.1 (247864..252637)	None
genomic	CH471152.1	EAW60743.1
genomic	HC921481.1	CBU83086.1
genomic	HD063883.1	CBU30437.1
genomic	J03607.1	AAA36044.1
mRNA	AB041267.1	BAA94607.1
mRNA	AB041268.1	BAA94608.1
mRNA	AK313261.1	BAG36071.1
mRNA	BC002539.2	AAH02539.3
mRNA	BC007628.1	AAH07628.1
mRNA	BC010409.2	AAH10409.3
mRNA	BC067744.1	AAH67744.2
mRNA	BC084574.1	AAH84574.2
mRNA	BG490639.1	None
mRNA	BG750971.1	None
mRNA	BP328445.1	None
mRNA	DA068330.1	None
mRNA	Y00503.1	CAA68556.1
other-genetic	DQ892179.2	ABM83105.1
other-genetic	DQ895373.2	ABM86299.1