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    MED4 Mediator complex subunit 4 [ Drosophila melanogaster ]

    Gene ID: 38799, updated on 10-May-2012
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    Summary

    Official Symbol
    MED4provided by Flybase
    Official Full Name
    Mediator complex subunit 4provided by Flybase
    Primary source
    FLYBASE:FBgn0035754
    Locus tag
    Dmel_CG8609
    Gene type
    protein coding
    RNA name
    mediator complex subunit 4
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8609; Dmel\CG8609; dp34; dTRAP36; Med4; Med4/TRAP36; p34; Trap36
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    Genomic context

    Location :
    65E9-65E9
    Sequence :
    Chromosome: 3L; NT_037436.3 (7242629..7243623, complement)
    See MED4 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene meiotic P22 Neighboring gene CG8610 gene product from transcript CG8610-RA Neighboring gene ncRNA Neighboring gene CG14830 gene product from transcript CG14830-RC Neighboring gene CG32381 gene product from transcript CG32381-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Kondo S, et al. Sci Signal, 2011 Jan 4. PMID 21205937.
    3. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    4. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    5. Coactivator cross-talk specifies transcriptional output. Marr MT 2nd, et al. Genes Dev, 2006 Jun 1. PMID 16751183.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_648094.1 NP_648849.2 MED10    BIND  PubMed Nut2 interacts with Trap36 
    NP_648094.1 NP_649057.1 MED11    BIND  PubMed Trap19 interacts with Trap36 
    BioGRID:64242 BioGRID:61091 Acp36DE    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:64801 Atg1    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:58653 Bap60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:63895 CG11505    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:59096 CG12985    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:58285 CG15365    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:59864 CG15631    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:60802 CG15638    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:61499 CG17002    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:65937 CG2017    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:59881 CG3008    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:71394 CG3287    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:77797 CG33275    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:60444 CG34159    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:67319 CG3517    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:78248 CG40006    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:59077 CG42684    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:67481 CG5802    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:60616 CG6287    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:64355 CG7185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:67172 CG7379    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:64639 CG7600    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:65440 CG7757    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:63664 CG9205    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:64544 Cdk8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:62712 HLH54F    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:65085 MED10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:65323 MED11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:63628 MED14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:59479 MED15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:63152 MED16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:67196 MED17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:57686 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:68741 MED20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:63250 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:65902 MED27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:63633 MED30    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:69231 MED6    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:64242 BioGRID:66432 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:62960 MED8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:62760 MED9    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:60443 RpL7    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:67198 Ssdp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:66226 Tcp-1eta    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:62348 Tfb1    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:71878 boca    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:65055 brm    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:62251 cnn    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:67276 dnk    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:58490 dsh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:59468 ebi    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:69950 ix    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:66656 mbo    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:66996 mor    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:68960 ome    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:67375 psidin    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:64891 ptip    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:59774 sec5    BioGRID  PubMed Two-hybrid 
    BioGRID:64242 BioGRID:68707 skd    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64242 BioGRID:66026 zen    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the MED4 gene: The MED4 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    RNA polymerase II transcription cofactor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    RNA polymerase II transcription cofactor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic cell cycle G2/M transition DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		  
    muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG8609 gene product from transcript CG8609-RA
    Names
    CG8609-PA
    MED4-PA
    mediator
    mediator complex subunit 4
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      7242629..7243623, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139837.2 → NP_648094.1  mediator complex subunit 4 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VS38
      Related
      FBpp0076599, FBtr0076889
      Conserved Domains (1) summary
      pfam10018
      Location:47 – 189
      Blast Score: 284
      Med4; Vitamin-D-receptor interacting Mediator subunit 4
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAF50591.1
    mRNA AY061502.1 AAL29050.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS38.1 GenPept
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    Additional Links

    Gene LinkOut

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